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- NCIT_C173729 IAO_0000115 "A recombinant human adenoviral (rAd)-based vaccine encoding for the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunomodulating and anti-COVID-19 activities. Gam-COVID-Vac contains two components: a rAd type 26 (rAd26) prime component encoding the SARS-CoV-2 S protein gene and a rAd type 5 (rAd5) boost component encoding the SARS-CoV-2 S protein gene. Upon intramuscular administration of the Gam-COVID-Vac, the Ad infects cells and produces SP. The released SP activates the immune system to induce a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection and inhibit viral replication. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus." @default.
- NCIT_C173729 NCIT_NHC0 "C173729" @default.
- NCIT_C173729 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173729 NCIT_P106 "Virus" @default.
- NCIT_C173729 NCIT_P108 "COVID-19 Vaccine Gam-COVID-Vac" @default.
- NCIT_C173729 NCIT_P208 "CL1407551" @default.
- NCIT_C173729 NCIT_P322 "SeroNet" @default.
- NCIT_C173729 normalizedInformationContent "100" @default.
- NCIT_C173729 referenceCount "1" @default.
- NCIT_C173729 hasExactSynonym "COVID-19 Vaccine Gam-COVID-Vac" @default.
- NCIT_C173729 hasExactSynonym "Gam-COVID-Vac" @default.
- NCIT_C173729 hasExactSynonym "Sputnik V COVID-19 Vaccine" @default.
- NCIT_C173729 hasExactSynonym "rAd26/rAd5-expressing SARS-CoV-2 SP Vaccine Gam-COVID-Vac" @default.
- NCIT_C173729 inSubset NCIT_C173381 @default.
- NCIT_C173729 inSubset NCIT_C173383 @default.
- NCIT_C173729 inSubset NCIT_C179027 @default.
- NCIT_C173729 inSubset NCIT_C189083 @default.
- NCIT_C173729 type Class @default.
- NCIT_C173729 isDefinedBy ncit.owl @default.
- NCIT_C173729 label "COVID-19 Vaccine Gam-COVID-Vac" @default.
- NCIT_C173729 subClassOf NCIT_C1572 @default.
- NCIT_C173729 subClassOf NCIT_C173023 @default.
- NCIT_C173729 subClassOf NCIT_C173729 @default.
- NCIT_C173729 subClassOf NCIT_C1908 @default.
- NCIT_C173729 subClassOf NCIT_C1909 @default.
- NCIT_C173729 subClassOf NCIT_C307 @default.
- NCIT_C173729 subClassOf NCIT_C308 @default.
- NCIT_C173729 subClassOf NCIT_C923 @default.
- NCIT_C173729 subClassOf NCIT_C96404 @default.