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- NCIT_C173743 IAO_0000115 "A combination of two monoclonal antibodies, casirivimab and imdevimab, directed against the spike protein (SP) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. Upon administration, casirivimab and imdevimab specifically target and bind to non-overlapping regions of the receptor-binding domain (RBD) of SP, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. Binding to two distinct regions of the RBD of SP may decrease the potential for virus escape mutants that occur upon treatment with a single SARS-CoV-2 antibody, and may provide enhanced protection against loss of efficacy." @default.
- NCIT_C173743 NCIT_A48 NCIT_C17998 @default.
- NCIT_C173743 NCIT_A48 NCIT_C49487 @default.
- NCIT_C173743 NCIT_A48 NCIT_C49488 @default.
- NCIT_C173743 NCIT_A7 NCIT_C178209 @default.
- NCIT_C173743 NCIT_NHC0 "C173743" @default.
- NCIT_C173743 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C173743 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173743 NCIT_P107 "Casirivimab/Imdevimab" @default.
- NCIT_C173743 NCIT_P108 "Casirivimab/Imdevimab" @default.
- NCIT_C173743 NCIT_P208 "CL1656919" @default.
- NCIT_C173743 NCIT_P302 "emergency use authorization (EUA) : for emergency use as post-exposure prophylaxis (prevention) for COVID-19 in adults and pediatric individuals (12 years of age and older weighing at least 40 kg) who are at high risk for progression to severe COVID-19, including hospitalization or death." @default.
- NCIT_C173743 NCIT_P322 "ACC/AHA" @default.
- NCIT_C173743 NCIT_P322 "CTRP" @default.
- NCIT_C173743 NCIT_P399 "809890" @default.
- NCIT_C173743 NCIT_R124 NCIT_C17710 @default.
- NCIT_C173743 NCIT_R124 NCIT_C17828 @default.
- NCIT_C173743 NCIT_R124 NCIT_C18219 @default.
- NCIT_C173743 NCIT_R124 NCIT_C19986 @default.
- NCIT_C173743 NCIT_R124 NCIT_C40474 @default.
- NCIT_C173743 normalizedInformationContent "100" @default.
- NCIT_C173743 referenceCount "1" @default.
- NCIT_C173743 hasExactSynonym "Anti-COVID Cocktail REGN-COV2" @default.
- NCIT_C173743 hasExactSynonym "Anti-Spike SARS-CoV-2 Monoclonal Antibodies REGN-COV2" @default.
- NCIT_C173743 hasExactSynonym "Casirivimab Plus Imdevimab" @default.
- NCIT_C173743 hasExactSynonym "Casirivimab and Imdevimab" @default.
- NCIT_C173743 hasExactSynonym "Casirivimab+Imdevimab" @default.
- NCIT_C173743 hasExactSynonym "Casirivimab/Imdevimab" @default.
- NCIT_C173743 hasExactSynonym "Monoclonal antibodies against SARS-CoV-2: casirivimab/imdevimab" @default.
- NCIT_C173743 hasExactSynonym "REGEN-COV" @default.
- NCIT_C173743 hasExactSynonym "REGN COV2" @default.
- NCIT_C173743 hasExactSynonym "REGN-COV2" @default.
- NCIT_C173743 hasExactSynonym "REGN10933 Plus REGN10987" @default.
- NCIT_C173743 hasExactSynonym "REGN10933+REGN10987" @default.
- NCIT_C173743 hasExactSynonym "REGN10933/REGN10987" @default.
- NCIT_C173743 hasExactSynonym "REGNCOV2" @default.
- NCIT_C173743 hasExactSynonym "SARS-CoV-2-specific Antibodies REGN10933 and REGN10987" @default.
- NCIT_C173743 inSubset NCIT_C116977 @default.
- NCIT_C173743 inSubset NCIT_C116978 @default.
- NCIT_C173743 inSubset NCIT_C173381 @default.
- NCIT_C173743 inSubset NCIT_C173383 @default.
- NCIT_C173743 inSubset NCIT_C176424 @default.
- NCIT_C173743 inSubset NCIT_C191200 @default.
- NCIT_C173743 inSubset NCIT_C191387 @default.
- NCIT_C173743 inSubset NCIT_C191404 @default.
- NCIT_C173743 inSubset NCIT_C191670 @default.
- NCIT_C173743 type Class @default.
- NCIT_C173743 isDefinedBy ncit.owl @default.
- NCIT_C173743 label "Casirivimab/Imdevimab" @default.
- NCIT_C173743 subClassOf NCIT_C173741 @default.
- NCIT_C173743 subClassOf NCIT_C173743 @default.
- NCIT_C173743 subClassOf NCIT_C1908 @default.
- NCIT_C173743 subClassOf NCIT_C1909 @default.
- NCIT_C173743 subClassOf NCIT_C20401 @default.
- NCIT_C173743 subClassOf NCIT_C307 @default.
- NCIT_C173743 subClassOf NCIT_C308 @default.