Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C173857> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- NCIT_C173857 IAO_0000115 "A fixed combination of atazanavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, and ritonavir, a cytochrome P450 3A4 (CYP3A4) inhibitor, that may be used to treat HIV-1 infection. Upon oral administration of atazanavir/ritonavir, atazanavir selectively binds to the active site of HIV-1 protease and inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions. Ritonavir inhibits CYP3A4, thereby limiting the metabolism of atazanavir, which is a CYP3A4 substrate, and increasing its systemic exposure. This leads to an increased concentration and half-life of atazanavir as compared to the administration of atazanavir without ritonavir." @default.
- NCIT_C173857 NCIT_NHC0 "C173857" @default.
- NCIT_C173857 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173857 NCIT_P107 "Atazanavir/ritonavir" @default.
- NCIT_C173857 NCIT_P108 "Atazanavir/Ritonavir" @default.
- NCIT_C173857 NCIT_P207 "C1977391" @default.
- NCIT_C173857 NCIT_P322 "CTRP" @default.
- NCIT_C173857 NCIT_P399 "811243" @default.
- NCIT_C173857 normalizedInformationContent "100" @default.
- NCIT_C173857 referenceCount "1" @default.
- NCIT_C173857 hasExactSynonym "Anzavir-R" @default.
- NCIT_C173857 hasExactSynonym "Atazanavir-Ritonavir" @default.
- NCIT_C173857 hasExactSynonym "Atazanavir/Ritonavir" @default.
- NCIT_C173857 hasExactSynonym "Atazanavir/ritonavir" @default.
- NCIT_C173857 hasExactSynonym "Ritonavir/Atazanavir" @default.
- NCIT_C173857 inSubset NCIT_C116977 @default.
- NCIT_C173857 inSubset NCIT_C116978 @default.
- NCIT_C173857 inSubset NCIT_C173381 @default.
- NCIT_C173857 inSubset NCIT_C173383 @default.
- NCIT_C173857 inSubset NCIT_C176424 @default.
- NCIT_C173857 type Class @default.
- NCIT_C173857 isDefinedBy ncit.owl @default.
- NCIT_C173857 label "Atazanavir/Ritonavir" @default.
- NCIT_C173857 subClassOf NCIT_C1660 @default.
- NCIT_C173857 subClassOf NCIT_C173857 @default.
- NCIT_C173857 subClassOf NCIT_C1908 @default.
- NCIT_C173857 subClassOf NCIT_C1909 @default.
- NCIT_C173857 subClassOf NCIT_C254 @default.
- NCIT_C173857 subClassOf NCIT_C281 @default.
- NCIT_C173857 subClassOf NCIT_C471 @default.
- NCIT_C173857 subClassOf NCIT_C783 @default.
- NCIT_C173857 subClassOf NCIT_C97366 @default.