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- NCIT_C173879 IAO_0000115 "An orally bioavailable nanoparticle-based formulation composed of sub-micron particles of the macrolide antibiotic rapamycin incorporated into a pH-sensitive poly(methyl methacrylate) polymer, with potential immunomodulating and antineoplastic activities. Upon oral administration of the encapsulated rapamycin, the nanoparticle specifically delivers rapamycin at the tumor site. Rapamycin binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits the activation of the serine/threonine kinase mammalian target of rapamycin (mTOR), a key regulatory kinase. This may suppress mTORC1 activity. In addition, inhibition of mTOR may modulate central memory CD8 T cells, CD3+/CD56+ natural killer (NK) cells and CD8 T-cell responses. This may kill tumor cells. Compared to the administration of rapamycin alone, this formulation improves oral bioavailability of rapamycin with more consistent rapamycin levels, thereby allowing for administration of lower rapamycin dosage, which improves and minimizes rapamycin's toxicity. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway." @default.
- NCIT_C173879 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173879 NCIT_A7 NCIT_C102485 @default.
- NCIT_C173879 NCIT_A7 NCIT_C38929 @default.
- NCIT_C173879 NCIT_A7 NCIT_C96314 @default.
- NCIT_C173879 NCIT_A7 NCIT_C96315 @default.
- NCIT_C173879 NCIT_NHC0 "C173879" @default.
- NCIT_C173879 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173879 NCIT_P107 "Encapsulated Rapamycin" @default.
- NCIT_C173879 NCIT_P108 "Encapsulated Rapamycin" @default.
- NCIT_C173879 NCIT_P208 "CL1407680" @default.
- NCIT_C173879 NCIT_P322 "CTRP" @default.
- NCIT_C173879 NCIT_P322 "GDC" @default.
- NCIT_C173879 NCIT_P329 "802399" @default.
- NCIT_C173879 NCIT_P330 "802399" @default.
- NCIT_C173879 NCIT_P375 "Encapsulated Rapamycin" @default.
- NCIT_C173879 NCIT_P399 "802399" @default.
- NCIT_C173879 normalizedInformationContent "100" @default.
- NCIT_C173879 referenceCount "1" @default.
- NCIT_C173879 hasExactSynonym "Encapsulated Rapamycin" @default.
- NCIT_C173879 hasExactSynonym "Encapsulated Sirolimus" @default.
- NCIT_C173879 hasExactSynonym "Microencapsulated Rapamycin" @default.
- NCIT_C173879 hasExactSynonym "eRapa (TM)" @default.
- NCIT_C173879 inSubset NCIT_C116977 @default.
- NCIT_C173879 inSubset NCIT_C116978 @default.
- NCIT_C173879 inSubset NCIT_C128784 @default.
- NCIT_C173879 inSubset NCIT_C157711 @default.
- NCIT_C173879 inSubset NCIT_C157712 @default.
- NCIT_C173879 inSubset NCIT_C176424 @default.
- NCIT_C173879 inSubset NCIT_C177537 @default.
- NCIT_C173879 type Class @default.
- NCIT_C173879 isDefinedBy ncit.owl @default.
- NCIT_C173879 label "Encapsulated Rapamycin" @default.
- NCIT_C173879 subClassOf NCIT_C129824 @default.
- NCIT_C173879 subClassOf NCIT_C129825 @default.
- NCIT_C173879 subClassOf NCIT_C1404 @default.
- NCIT_C173879 subClassOf NCIT_C163758 @default.
- NCIT_C173879 subClassOf NCIT_C173879 @default.
- NCIT_C173879 subClassOf NCIT_C1908 @default.
- NCIT_C173879 subClassOf NCIT_C1909 @default.
- NCIT_C173879 subClassOf NCIT_C2189 @default.
- NCIT_C173879 subClassOf NCIT_C2201 @default.
- NCIT_C173879 subClassOf NCIT_C274 @default.
- NCIT_C173879 subClassOf NCIT_C471 @default.
- NCIT_C173879 subClassOf NCIT_C61074 @default.