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- NCIT_C173889 IAO_0000115 "An attenuated oncolytic Edmonston (Ed) strain of measles virus (MV) encoding the N-terminus of the human lambda immunoglobulin light chain containing the Helicobacter pylori neutrophil-activating protein (NAP), with potential immunostimulating and antineoplastic activities. Upon administration, the oncolytic measles virus encoding H. pylori NAP selectively infects and replicates in tumor cells, leading to syncytia formation and tumor cell lysis. The expressed NAP, a toll-like receptor-2 (TLR2) agonist, may stimulate the secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1 and IL-6, leading to local inflammatory reaction in the tumor microenvironment (TME). H. pylori NAP, a bacterial antigen and potent immunomodulator, may enhance the antitumor effect of oncolytic MV." @default.
- NCIT_C173889 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173889 NCIT_NHC0 "C173889" @default.
- NCIT_C173889 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173889 NCIT_P106 "Virus" @default.
- NCIT_C173889 NCIT_P107 "Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein" @default.
- NCIT_C173889 NCIT_P108 "Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein" @default.
- NCIT_C173889 NCIT_P208 "CL1407687" @default.
- NCIT_C173889 NCIT_P322 "CTRP" @default.
- NCIT_C173889 NCIT_P322 "GDC" @default.
- NCIT_C173889 NCIT_P329 "802401" @default.
- NCIT_C173889 NCIT_P330 "802401" @default.
- NCIT_C173889 NCIT_P375 "Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein" @default.
- NCIT_C173889 NCIT_P399 "802401" @default.
- NCIT_C173889 normalizedInformationContent "100" @default.
- NCIT_C173889 referenceCount "1" @default.
- NCIT_C173889 hasExactSynonym "MV Encoding NAP" @default.
- NCIT_C173889 hasExactSynonym "MV-s-NAP" @default.
- NCIT_C173889 hasExactSynonym "Oncolytic Measles Virus Encoding H. pylori NAP" @default.
- NCIT_C173889 hasExactSynonym "Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein" @default.
- NCIT_C173889 inSubset NCIT_C116977 @default.
- NCIT_C173889 inSubset NCIT_C116978 @default.
- NCIT_C173889 inSubset NCIT_C128784 @default.
- NCIT_C173889 inSubset NCIT_C157711 @default.
- NCIT_C173889 inSubset NCIT_C157712 @default.
- NCIT_C173889 inSubset NCIT_C176424 @default.
- NCIT_C173889 inSubset NCIT_C177537 @default.
- NCIT_C173889 type Class @default.
- NCIT_C173889 isDefinedBy ncit.owl @default.
- NCIT_C173889 label "Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein" @default.
- NCIT_C173889 subClassOf NCIT_C129821 @default.
- NCIT_C173889 subClassOf NCIT_C173889 @default.
- NCIT_C173889 subClassOf NCIT_C1908 @default.
- NCIT_C173889 subClassOf NCIT_C1909 @default.
- NCIT_C173889 subClassOf NCIT_C1962 @default.
- NCIT_C173889 subClassOf NCIT_C274 @default.
- NCIT_C173889 subClassOf NCIT_C307 @default.
- NCIT_C173889 subClassOf NCIT_C717 @default.