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- NCIT_C173946 IAO_0000115 "An antibody drug conjugate (ADC) composed of farletuzumab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the folate receptor alpha (FRA; FolRa; FOLR1), and conjugated, via a cathepsin B-cleavable linker, to the microtubule-targeting agent (MTA) eribulin, a derivative of the macrocyclic polyether natural product halichondrin B, with potential antineoplastic activity. Upon administration of farletuzumab ecteribulin, the farletuzumab moiety targets and binds to FRA expressed on certain tumor cells. Upon binding, internalization, and enzymatic cleavage, eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and the induction of tumor cell death in FRA-expressing cells. FRA is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues." @default.
- NCIT_C173946 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173946 NCIT_A7 NCIT_C39284 @default.
- NCIT_C173946 NCIT_NHC0 "C173946" @default.
- NCIT_C173946 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173946 NCIT_P107 "Farletuzumab Ecteribulin" @default.
- NCIT_C173946 NCIT_P108 "Farletuzumab Ecteribulin" @default.
- NCIT_C173946 NCIT_P208 "CL1407865" @default.
- NCIT_C173946 NCIT_P210 "2407465-18-1" @default.
- NCIT_C173946 NCIT_P319 "UVG3B5TZN3" @default.
- NCIT_C173946 NCIT_P322 "CTRP" @default.
- NCIT_C173946 NCIT_P322 "FDA" @default.
- NCIT_C173946 NCIT_P322 "GDC" @default.
- NCIT_C173946 NCIT_P329 "802404" @default.
- NCIT_C173946 NCIT_P330 "802404" @default.
- NCIT_C173946 NCIT_P375 "Anti-FRA/Eribulin Antibody-drug Conjugate MORAb-202" @default.
- NCIT_C173946 NCIT_P399 "802404" @default.
- NCIT_C173946 normalizedInformationContent "100" @default.
- NCIT_C173946 referenceCount "1" @default.
- NCIT_C173946 hasExactSynonym "ADC MORAb-202" @default.
- NCIT_C173946 hasExactSynonym "Anti-FRA ADC MORAb-202" @default.
- NCIT_C173946 hasExactSynonym "Anti-FRA/Eribulin ADC MORAb-202" @default.
- NCIT_C173946 hasExactSynonym "Anti-FRA/Eribulin Antibody-drug Conjugate MORAb-202" @default.
- NCIT_C173946 hasExactSynonym "FARLETUZUMAB ECTERIBULIN" @default.
- NCIT_C173946 hasExactSynonym "Farletuzumab Ecteribulin" @default.
- NCIT_C173946 hasExactSynonym "MORAb 202" @default.
- NCIT_C173946 hasExactSynonym "MORAb-202" @default.
- NCIT_C173946 hasExactSynonym "MORAb202" @default.
- NCIT_C173946 inSubset NCIT_C116977 @default.
- NCIT_C173946 inSubset NCIT_C116978 @default.
- NCIT_C173946 inSubset NCIT_C128784 @default.
- NCIT_C173946 inSubset NCIT_C157711 @default.
- NCIT_C173946 inSubset NCIT_C157712 @default.
- NCIT_C173946 inSubset NCIT_C176424 @default.
- NCIT_C173946 inSubset NCIT_C177537 @default.
- NCIT_C173946 inSubset NCIT_C63923 @default.
- NCIT_C173946 type Class @default.
- NCIT_C173946 isDefinedBy ncit.owl @default.
- NCIT_C173946 label "Farletuzumab Ecteribulin" @default.
- NCIT_C173946 subClassOf NCIT_C129821 @default.
- NCIT_C173946 subClassOf NCIT_C129823 @default.
- NCIT_C173946 subClassOf NCIT_C1512 @default.
- NCIT_C173946 subClassOf NCIT_C163758 @default.
- NCIT_C173946 subClassOf NCIT_C173946 @default.
- NCIT_C173946 subClassOf NCIT_C1908 @default.
- NCIT_C173946 subClassOf NCIT_C1909 @default.
- NCIT_C173946 subClassOf NCIT_C200086 @default.
- NCIT_C173946 subClassOf NCIT_C200114 @default.
- NCIT_C173946 subClassOf NCIT_C274 @default.
- NCIT_C173946 subClassOf NCIT_C307 @default.
- NCIT_C173946 subClassOf NCIT_C308 @default.