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- NCIT_C173959 IAO_0000115 "A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T-lymphocytes expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD19 universal CAR-T cells CTA101 specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. CTA101 is genetically engineered to prevent graft-versus-host disease (GvHD) by the donor T-cells. OTS CAR-T cells require reduced production times when compared to autologous CAR-T cells." @default.
- NCIT_C173959 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173959 NCIT_NHC0 "C173959" @default.
- NCIT_C173959 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173959 NCIT_P108 "Allogeneic Anti-CD19 Universal CAR-T Cells CTA101" @default.
- NCIT_C173959 NCIT_P208 "CL1407868" @default.
- NCIT_C173959 NCIT_P322 "GDC" @default.
- NCIT_C173959 NCIT_P329 "802167" @default.
- NCIT_C173959 NCIT_P330 "802167" @default.
- NCIT_C173959 NCIT_P375 "Allogeneic Anti-CD19 Universal CAR-T Cells CTA101" @default.
- NCIT_C173959 NCIT_P399 "802167" @default.
- NCIT_C173959 normalizedInformationContent "100" @default.
- NCIT_C173959 referenceCount "1" @default.
- NCIT_C173959 hasExactSynonym "Allogeneic Anti-CD19 UCAR-T Cells CTA101" @default.
- NCIT_C173959 hasExactSynonym "Allogeneic Anti-CD19 Universal CAR-T Cells CTA101" @default.
- NCIT_C173959 hasExactSynonym "CTA 101" @default.
- NCIT_C173959 hasExactSynonym "CTA-101" @default.
- NCIT_C173959 hasExactSynonym "CTA101" @default.
- NCIT_C173959 hasExactSynonym "Universal CD19-directed CAR-T Cells CTA101" @default.
- NCIT_C173959 inSubset NCIT_C128784 @default.
- NCIT_C173959 inSubset NCIT_C157711 @default.
- NCIT_C173959 inSubset NCIT_C157712 @default.
- NCIT_C173959 inSubset NCIT_C176424 @default.
- NCIT_C173959 inSubset NCIT_C177537 @default.
- NCIT_C173959 type Class @default.
- NCIT_C173959 isDefinedBy ncit.owl @default.
- NCIT_C173959 label "Allogeneic Anti-CD19 Universal CAR-T Cells CTA101" @default.
- NCIT_C173959 subClassOf NCIT_C129820 @default.
- NCIT_C173959 subClassOf NCIT_C129821 @default.
- NCIT_C173959 subClassOf NCIT_C129826 @default.
- NCIT_C173959 subClassOf NCIT_C137999 @default.
- NCIT_C173959 subClassOf NCIT_C142078 @default.
- NCIT_C173959 subClassOf NCIT_C154231 @default.
- NCIT_C173959 subClassOf NCIT_C173959 @default.
- NCIT_C173959 subClassOf NCIT_C176018 @default.
- NCIT_C173959 subClassOf NCIT_C1908 @default.
- NCIT_C173959 subClassOf NCIT_C1909 @default.
- NCIT_C173959 subClassOf NCIT_C1962 @default.
- NCIT_C173959 subClassOf NCIT_C200765 @default.
- NCIT_C173959 subClassOf NCIT_C274 @default.
- NCIT_C173959 subClassOf NCIT_C28676 @default.
- NCIT_C173959 subClassOf NCIT_C307 @default.
- NCIT_C173959 subClassOf NCIT_C308 @default.