Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C173967> ?p ?o ?g. }
Showing items 1 to 42 of
42
with 100 items per page.
- NCIT_C173967 IAO_0000115 "A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting both the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-BCMA/CS1 bispecific CAR-T cells target and bind to tumor cells expressing BCMA and/or CS1 and induce selective cytotoxicity in those cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells. Targeting the two different TAAs highly expressed on malignant plasma cells may improve coverage and protect against antigen escape and resistance as tumor cells would need to lose both antigens." @default.
- NCIT_C173967 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173967 NCIT_NHC0 "C173967" @default.
- NCIT_C173967 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173967 NCIT_P108 "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells" @default.
- NCIT_C173967 NCIT_P208 "CL1407845" @default.
- NCIT_C173967 NCIT_P322 "GDC" @default.
- NCIT_C173967 NCIT_P329 "802179" @default.
- NCIT_C173967 NCIT_P330 "802179" @default.
- NCIT_C173967 NCIT_P375 "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells" @default.
- NCIT_C173967 NCIT_P399 "802179" @default.
- NCIT_C173967 normalizedInformationContent "100" @default.
- NCIT_C173967 referenceCount "1" @default.
- NCIT_C173967 hasExactSynonym "Allogeneic Anti-BCMA/CS1 Bispecific CAR T-cells" @default.
- NCIT_C173967 hasExactSynonym "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells" @default.
- NCIT_C173967 hasExactSynonym "Allogeneic Anti-BCMA/SLAMF7 Bispecific CAR-T Cells" @default.
- NCIT_C173967 hasExactSynonym "Allogeneic BCMA/CS1 Bispecific CAR-T Cells" @default.
- NCIT_C173967 hasExactSynonym "Allogeneic BCMA/SLAMF7 Bispecific CAR-T Cells" @default.
- NCIT_C173967 inSubset NCIT_C128784 @default.
- NCIT_C173967 inSubset NCIT_C157711 @default.
- NCIT_C173967 inSubset NCIT_C157712 @default.
- NCIT_C173967 inSubset NCIT_C176424 @default.
- NCIT_C173967 inSubset NCIT_C177537 @default.
- NCIT_C173967 type Class @default.
- NCIT_C173967 isDefinedBy ncit.owl @default.
- NCIT_C173967 label "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells" @default.
- NCIT_C173967 subClassOf NCIT_C129820 @default.
- NCIT_C173967 subClassOf NCIT_C129821 @default.
- NCIT_C173967 subClassOf NCIT_C129826 @default.
- NCIT_C173967 subClassOf NCIT_C137999 @default.
- NCIT_C173967 subClassOf NCIT_C142078 @default.
- NCIT_C173967 subClassOf NCIT_C154231 @default.
- NCIT_C173967 subClassOf NCIT_C173967 @default.
- NCIT_C173967 subClassOf NCIT_C176023 @default.
- NCIT_C173967 subClassOf NCIT_C1908 @default.
- NCIT_C173967 subClassOf NCIT_C1909 @default.
- NCIT_C173967 subClassOf NCIT_C1962 @default.
- NCIT_C173967 subClassOf NCIT_C200765 @default.
- NCIT_C173967 subClassOf NCIT_C274 @default.
- NCIT_C173967 subClassOf NCIT_C28676 @default.
- NCIT_C173967 subClassOf NCIT_C307 @default.
- NCIT_C173967 subClassOf NCIT_C308 @default.