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- NCIT_C173970 IAO_0000115 "A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the CD123 (interleukin-3 receptor alpha chain or IL3RA) antigen and one specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, the CD123-CD33 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing CD123 and/or CD33. This induces selective toxicity in tumor cells that express the CD123 antigen and/or the CD33 antigen. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens. Additionally, the CD123-CD33 cCAR T cells express CD52 on the cell surface. This allows the depletion of the CD123-CD33 cCAR T cells with the administration of the anti-CD52 monoclonal antibody alemtuzumab, in case of unacceptable side effects." @default.
- NCIT_C173970 NCIT_A32 NCIT_C1909 @default.
- NCIT_C173970 NCIT_NHC0 "C173970" @default.
- NCIT_C173970 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173970 NCIT_P108 "CD123-CD33 Compound CAR T Cells" @default.
- NCIT_C173970 NCIT_P208 "CL1407854" @default.
- NCIT_C173970 NCIT_P322 "GDC" @default.
- NCIT_C173970 NCIT_P329 "802178" @default.
- NCIT_C173970 NCIT_P330 "802178" @default.
- NCIT_C173970 NCIT_P375 "CD123-CD33 Compound CAR T Cells" @default.
- NCIT_C173970 NCIT_P399 "802178" @default.
- NCIT_C173970 normalizedInformationContent "100" @default.
- NCIT_C173970 referenceCount "1" @default.
- NCIT_C173970 hasExactSynonym "123b-33bcCAR T-cells" @default.
- NCIT_C173970 hasExactSynonym "CD123-CD33 Compound CAR T Cells" @default.
- NCIT_C173970 hasExactSynonym "CD123-CD33 cCAR T Cells" @default.
- NCIT_C173970 hasExactSynonym "CD123-CD33 cCAR T-cells" @default.
- NCIT_C173970 hasExactSynonym "CD123/CD33-expressing Compound CAR-T Cells" @default.
- NCIT_C173970 inSubset NCIT_C128784 @default.
- NCIT_C173970 inSubset NCIT_C157711 @default.
- NCIT_C173970 inSubset NCIT_C157712 @default.
- NCIT_C173970 inSubset NCIT_C176424 @default.
- NCIT_C173970 inSubset NCIT_C177537 @default.
- NCIT_C173970 type Class @default.
- NCIT_C173970 isDefinedBy ncit.owl @default.
- NCIT_C173970 label "CD123-CD33 Compound CAR T Cells" @default.
- NCIT_C173970 subClassOf NCIT_C129820 @default.
- NCIT_C173970 subClassOf NCIT_C129821 @default.
- NCIT_C173970 subClassOf NCIT_C129826 @default.
- NCIT_C173970 subClassOf NCIT_C137999 @default.
- NCIT_C173970 subClassOf NCIT_C142078 @default.
- NCIT_C173970 subClassOf NCIT_C154231 @default.
- NCIT_C173970 subClassOf NCIT_C173970 @default.
- NCIT_C173970 subClassOf NCIT_C1908 @default.
- NCIT_C173970 subClassOf NCIT_C1909 @default.
- NCIT_C173970 subClassOf NCIT_C1962 @default.
- NCIT_C173970 subClassOf NCIT_C201493 @default.
- NCIT_C173970 subClassOf NCIT_C201495 @default.
- NCIT_C173970 subClassOf NCIT_C274 @default.
- NCIT_C173970 subClassOf NCIT_C307 @default.
- NCIT_C173970 subClassOf NCIT_C308 @default.