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- NCIT_C173983 IAO_0000115 "An agonistic, recombinant, humanized, hexavalent immunoglobulin G (IgG) antibody targeting the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory and antineoplastic activities. Upon administration, anti-OX40 hexavalent agonist antibody INBRX-106 selectively binds to six OX40 receptors per molecule, thereby clustering and activating OX40. This induces the proliferation of memory and effector T-lymphocytes and results in a T-cell-mediated immune response against tumor cells, which leads to tumor cell lysis. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and provides a co-stimulatory signal that promotes both the proliferation and survival of activated T-cells. Utilizing a hexavalent OX40 antibody may improve receptor clustering and downstream signaling over tetravalent or bivalent OX40 antibodies." @default.
- NCIT_C173983 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C173983 NCIT_NHC0 "C173983" @default.
- NCIT_C173983 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C173983 NCIT_P107 "Anti-OX40 Hexavalent Agonist Antibody INBRX-106" @default.
- NCIT_C173983 NCIT_P108 "Anti-OX40 Hexavalent Agonist Antibody INBRX-106" @default.
- NCIT_C173983 NCIT_P208 "CL1407892" @default.
- NCIT_C173983 NCIT_P322 "CTRP" @default.
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- NCIT_C173983 NCIT_P329 "802449" @default.
- NCIT_C173983 NCIT_P330 "802449" @default.
- NCIT_C173983 NCIT_P375 "Anti-OX40 Hexavalent Agonist Antibody INBRX-106" @default.
- NCIT_C173983 NCIT_P399 "802449" @default.
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- NCIT_C173983 normalizedInformationContent "100" @default.
- NCIT_C173983 referenceCount "1" @default.
- NCIT_C173983 hasExactSynonym "Anti-OX40 Agonistic Antibody INBRX-106" @default.
- NCIT_C173983 hasExactSynonym "Anti-OX40 Hexavalent Agonist Antibody INBRX-106" @default.
- NCIT_C173983 hasExactSynonym "ES 102" @default.
- NCIT_C173983 hasExactSynonym "ES-102" @default.
- NCIT_C173983 hasExactSynonym "ES102" @default.
- NCIT_C173983 hasExactSynonym "INBRX 106" @default.
- NCIT_C173983 hasExactSynonym "INBRX-106" @default.
- NCIT_C173983 hasExactSynonym "INBRX106" @default.
- NCIT_C173983 inSubset NCIT_C116977 @default.
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- NCIT_C173983 type Class @default.
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- NCIT_C173983 label "Anti-OX40 Hexavalent Agonist Antibody INBRX-106" @default.
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- NCIT_C173983 subClassOf NCIT_C274 @default.
- NCIT_C173983 subClassOf NCIT_C307 @default.
- NCIT_C173983 subClassOf NCIT_C308 @default.
- NCIT_C173983 subClassOf NCIT_C96040 @default.