Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C174049> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- NCIT_C174049 IAO_0000115 "An oncolytic vaccinia virus (VV; VACV) genetically engineered to express an Fms-like tyrosine kinase 3 (Flt3) ligand, an antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the human pro-inflammatory cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon administration of the Flt3 ligand/anti-CTLA-4 antibody/IL-12 engineered oncolytic VV RIVAL-01, the virus preferentially targets, infects and replicates in tumor cells, causing oncolysis. In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), which induce an immune response against the tumor cells. In addition, the Flt3 ligand, the anti-ctla-4 antibody and IL-12 are expressed by the VV in the cancer cells and may activate the immune system within the tumor microenvironment (TME), thereby stimulating both innate and adaptive immune responses. The anti-CTLA-4 antibody targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation, which promotes T-cell activation. Flt3 ligand binds to the Flt3 tyrosine kinase receptor and promotes Flt3 signaling which plays an important role in expanding the population of antigen-presenting dendritic cells (DCs). IL-12 activates natural killer cells (NKs), induces the secretion of interferon-gamma and promotes CD8 cytotoxic T-cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation." @default.
- NCIT_C174049 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174049 NCIT_NHC0 "C174049" @default.
- NCIT_C174049 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174049 NCIT_P106 "Virus" @default.
- NCIT_C174049 NCIT_P107 "Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus RIVAL-01" @default.
- NCIT_C174049 NCIT_P108 "Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus RIVAL-01" @default.
- NCIT_C174049 NCIT_P208 "CL1407953" @default.
- NCIT_C174049 NCIT_P322 "CTRP" @default.
- NCIT_C174049 NCIT_P322 "GDC" @default.
- NCIT_C174049 NCIT_P329 "802460" @default.
- NCIT_C174049 NCIT_P330 "802460" @default.
- NCIT_C174049 NCIT_P375 "Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus RIVAL-01" @default.
- NCIT_C174049 NCIT_P399 "802460" @default.
- NCIT_C174049 normalizedInformationContent "100" @default.
- NCIT_C174049 referenceCount "1" @default.
- NCIT_C174049 hasExactSynonym "Engineered Oncolytic Vaccinia Virus TBio-6517" @default.
- NCIT_C174049 hasExactSynonym "Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic VV RIVAL-01" @default.
- NCIT_C174049 hasExactSynonym "Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus RIVAL-01" @default.
- NCIT_C174049 hasExactSynonym "RIVAL 01" @default.
- NCIT_C174049 hasExactSynonym "RIVAL-01" @default.
- NCIT_C174049 hasExactSynonym "RIVAL01" @default.
- NCIT_C174049 hasExactSynonym "TAK-605" @default.
- NCIT_C174049 hasExactSynonym "TBio 6517" @default.
- NCIT_C174049 hasExactSynonym "TBio-6517" @default.
- NCIT_C174049 hasExactSynonym "TBio6517" @default.
- NCIT_C174049 inSubset NCIT_C116977 @default.
- NCIT_C174049 inSubset NCIT_C116978 @default.
- NCIT_C174049 inSubset NCIT_C128784 @default.
- NCIT_C174049 inSubset NCIT_C157711 @default.
- NCIT_C174049 inSubset NCIT_C157712 @default.
- NCIT_C174049 inSubset NCIT_C176424 @default.
- NCIT_C174049 inSubset NCIT_C177537 @default.
- NCIT_C174049 type Class @default.
- NCIT_C174049 isDefinedBy ncit.owl @default.
- NCIT_C174049 label "Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus RIVAL-01" @default.
- NCIT_C174049 subClassOf NCIT_C129821 @default.
- NCIT_C174049 subClassOf NCIT_C174049 @default.
- NCIT_C174049 subClassOf NCIT_C1908 @default.
- NCIT_C174049 subClassOf NCIT_C1909 @default.
- NCIT_C174049 subClassOf NCIT_C274 @default.
- NCIT_C174049 subClassOf NCIT_C307 @default.
- NCIT_C174049 subClassOf NCIT_C717 @default.