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- NCIT_C174400 IAO_0000115 "An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor ABBV-467 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival." @default.
- NCIT_C174400 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174400 NCIT_A7 NCIT_C17688 @default.
- NCIT_C174400 NCIT_NHC0 "C174400" @default.
- NCIT_C174400 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174400 NCIT_P107 "MCL-1 Inhibitor ABBV-467" @default.
- NCIT_C174400 NCIT_P108 "MCL-1 Inhibitor ABBV-467" @default.
- NCIT_C174400 NCIT_P208 "CL1411952" @default.
- NCIT_C174400 NCIT_P322 "CTRP" @default.
- NCIT_C174400 NCIT_P322 "GDC" @default.
- NCIT_C174400 NCIT_P329 "802326" @default.
- NCIT_C174400 NCIT_P330 "802326" @default.
- NCIT_C174400 NCIT_P375 "MCL-1 Inhibitor ABBV-467" @default.
- NCIT_C174400 NCIT_P399 "802326" @default.
- NCIT_C174400 normalizedInformationContent "100" @default.
- NCIT_C174400 referenceCount "1" @default.
- NCIT_C174400 hasExactSynonym "ABBV 467" @default.
- NCIT_C174400 hasExactSynonym "ABBV-467" @default.
- NCIT_C174400 hasExactSynonym "ABBV467" @default.
- NCIT_C174400 hasExactSynonym "MCL-1 Inhibitor ABBV-467" @default.
- NCIT_C174400 hasExactSynonym "Myeloid Cell Leukemia-1 Inhibitor ABBV-467" @default.
- NCIT_C174400 inSubset NCIT_C116977 @default.
- NCIT_C174400 inSubset NCIT_C116978 @default.
- NCIT_C174400 inSubset NCIT_C128784 @default.
- NCIT_C174400 inSubset NCIT_C157711 @default.
- NCIT_C174400 inSubset NCIT_C157712 @default.
- NCIT_C174400 inSubset NCIT_C176424 @default.
- NCIT_C174400 inSubset NCIT_C177537 @default.
- NCIT_C174400 type Class @default.
- NCIT_C174400 isDefinedBy ncit.owl @default.
- NCIT_C174400 label "MCL-1 Inhibitor ABBV-467" @default.
- NCIT_C174400 subClassOf NCIT_C129839 @default.
- NCIT_C174400 subClassOf NCIT_C137990 @default.
- NCIT_C174400 subClassOf NCIT_C174400 @default.
- NCIT_C174400 subClassOf NCIT_C1908 @default.
- NCIT_C174400 subClassOf NCIT_C1909 @default.
- NCIT_C174400 subClassOf NCIT_C192025 @default.
- NCIT_C174400 subClassOf NCIT_C274 @default.