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- NCIT_C174412 IAO_0000115 "A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and one specific for the TAA CD19, with potential immunomodulating and antineoplastic activities. Upon administration, the BCMA-CD19 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens." @default.
- NCIT_C174412 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174412 NCIT_NHC0 "C174412" @default.
- NCIT_C174412 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174412 NCIT_P108 "BCMA-CD19 Compound CAR T Cells" @default.
- NCIT_C174412 NCIT_P208 "CL1411933" @default.
- NCIT_C174412 NCIT_P322 "GDC" @default.
- NCIT_C174412 NCIT_P375 "BCMA/CD3e Tri-specific T-cell Activating Construct HPN217" @default.
- NCIT_C174412 normalizedInformationContent "100" @default.
- NCIT_C174412 referenceCount "1" @default.
- NCIT_C174412 hasExactSynonym "BCMA-CD19 Compound CAR T Cells" @default.
- NCIT_C174412 hasExactSynonym "BCMA-CD19 cCAR T Cells" @default.
- NCIT_C174412 hasExactSynonym "BCMA-CD19 cCAR T-cells" @default.
- NCIT_C174412 inSubset NCIT_C128784 @default.
- NCIT_C174412 inSubset NCIT_C157711 @default.
- NCIT_C174412 inSubset NCIT_C157712 @default.
- NCIT_C174412 inSubset NCIT_C177537 @default.
- NCIT_C174412 type Class @default.
- NCIT_C174412 isDefinedBy ncit.owl @default.
- NCIT_C174412 label "BCMA-CD19 Compound CAR T Cells" @default.
- NCIT_C174412 subClassOf NCIT_C129820 @default.
- NCIT_C174412 subClassOf NCIT_C129821 @default.
- NCIT_C174412 subClassOf NCIT_C129826 @default.
- NCIT_C174412 subClassOf NCIT_C137999 @default.
- NCIT_C174412 subClassOf NCIT_C142078 @default.
- NCIT_C174412 subClassOf NCIT_C154231 @default.
- NCIT_C174412 subClassOf NCIT_C174412 @default.
- NCIT_C174412 subClassOf NCIT_C176018 @default.
- NCIT_C174412 subClassOf NCIT_C176023 @default.
- NCIT_C174412 subClassOf NCIT_C1908 @default.
- NCIT_C174412 subClassOf NCIT_C1909 @default.
- NCIT_C174412 subClassOf NCIT_C1962 @default.
- NCIT_C174412 subClassOf NCIT_C274 @default.
- NCIT_C174412 subClassOf NCIT_C307 @default.
- NCIT_C174412 subClassOf NCIT_C308 @default.