Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C174417> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- NCIT_C174417 IAO_0000115 "An orally bioavailable selective inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6 inhibitor CS3002 selectively targets and inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation." @default.
- NCIT_C174417 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174417 NCIT_NHC0 "C174417" @default.
- NCIT_C174417 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174417 NCIT_P108 "CDK4/6 Inhibitor CS3002" @default.
- NCIT_C174417 NCIT_P208 "CL1411938" @default.
- NCIT_C174417 NCIT_P322 "GDC" @default.
- NCIT_C174417 NCIT_P329 "802263" @default.
- NCIT_C174417 NCIT_P330 "802263" @default.
- NCIT_C174417 NCIT_P375 "CDK4/6 Inhibitor CS3002" @default.
- NCIT_C174417 NCIT_P399 "802263" @default.
- NCIT_C174417 normalizedInformationContent "100" @default.
- NCIT_C174417 referenceCount "1" @default.
- NCIT_C174417 hasExactSynonym "CDK4/6 Inhibitor CS3002" @default.
- NCIT_C174417 hasExactSynonym "CS 3002" @default.
- NCIT_C174417 hasExactSynonym "CS-3002" @default.
- NCIT_C174417 hasExactSynonym "CS3002" @default.
- NCIT_C174417 inSubset NCIT_C128784 @default.
- NCIT_C174417 inSubset NCIT_C157711 @default.
- NCIT_C174417 inSubset NCIT_C157712 @default.
- NCIT_C174417 inSubset NCIT_C176424 @default.
- NCIT_C174417 inSubset NCIT_C177537 @default.
- NCIT_C174417 type Class @default.
- NCIT_C174417 isDefinedBy ncit.owl @default.
- NCIT_C174417 label "CDK4/6 Inhibitor CS3002" @default.
- NCIT_C174417 subClassOf NCIT_C129824 @default.
- NCIT_C174417 subClassOf NCIT_C129825 @default.
- NCIT_C174417 subClassOf NCIT_C1404 @default.
- NCIT_C174417 subClassOf NCIT_C163758 @default.
- NCIT_C174417 subClassOf NCIT_C174417 @default.
- NCIT_C174417 subClassOf NCIT_C1908 @default.
- NCIT_C174417 subClassOf NCIT_C1909 @default.
- NCIT_C174417 subClassOf NCIT_C192741 @default.
- NCIT_C174417 subClassOf NCIT_C192742 @default.
- NCIT_C174417 subClassOf NCIT_C2185 @default.
- NCIT_C174417 subClassOf NCIT_C2189 @default.
- NCIT_C174417 subClassOf NCIT_C274 @default.
- NCIT_C174417 subClassOf NCIT_C471 @default.
- NCIT_C174417 subClassOf NCIT_C61074 @default.