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- NCIT_C174419 IAO_0000115 "A recombinant human immunoglobulin G1 (IgG1) bispecific antibody directed against the human epidermal growth factor receptor 2 (HER2) and the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, fidasimtamab simultaneously targets, binds to and inhibits HER2 and PD-1 and their downstream signaling pathways, and bridges PD-1-expressing T-cells to HER2-expressing tumor cells. This may inhibit tumor cell proliferation of HER2-overexpressing cells. Inhibition of PD-1-mediated signaling may restore immune function through the activation of T-cells and T-cell-mediated immune responses against the HER2-expressing tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." @default.
- NCIT_C174419 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174419 NCIT_NHC0 "C174419" @default.
- NCIT_C174419 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174419 NCIT_P108 "Fidasimtamab" @default.
- NCIT_C174419 NCIT_P208 "CL1411981" @default.
- NCIT_C174419 NCIT_P210 "2377419-89-9" @default.
- NCIT_C174419 NCIT_P319 "JXN644CQ6P" @default.
- NCIT_C174419 NCIT_P322 "FDA" @default.
- NCIT_C174419 NCIT_P322 "GDC" @default.
- NCIT_C174419 NCIT_P329 "802264" @default.
- NCIT_C174419 NCIT_P330 "802264" @default.
- NCIT_C174419 NCIT_P375 "Anti-PD-1/Anti-HER2 Bispecific Antibody IBI315" @default.
- NCIT_C174419 NCIT_P399 "802264" @default.
- NCIT_C174419 NCIT_R124 NCIT_C17710 @default.
- NCIT_C174419 NCIT_R124 NCIT_C17828 @default.
- NCIT_C174419 NCIT_R124 NCIT_C18219 @default.
- NCIT_C174419 NCIT_R124 NCIT_C19986 @default.
- NCIT_C174419 NCIT_R124 NCIT_C40474 @default.
- NCIT_C174419 normalizedInformationContent "100" @default.
- NCIT_C174419 referenceCount "1" @default.
- NCIT_C174419 hasExactSynonym "Anti-PD-1/Anti-HER2 Bispecific Antibody IBI315" @default.
- NCIT_C174419 hasExactSynonym "BH 2950" @default.
- NCIT_C174419 hasExactSynonym "BH-2950" @default.
- NCIT_C174419 hasExactSynonym "BH2950" @default.
- NCIT_C174419 hasExactSynonym "FIDASIMTAMAB" @default.
- NCIT_C174419 hasExactSynonym "Fidasimtamab" @default.
- NCIT_C174419 hasExactSynonym "HER2/PD-1 Bi-specific Antibody BH 2950" @default.
- NCIT_C174419 hasExactSynonym "IBI 315" @default.
- NCIT_C174419 hasExactSynonym "IBI-315" @default.
- NCIT_C174419 hasExactSynonym "IBI315" @default.
- NCIT_C174419 inSubset NCIT_C128784 @default.
- NCIT_C174419 inSubset NCIT_C157711 @default.
- NCIT_C174419 inSubset NCIT_C157712 @default.
- NCIT_C174419 inSubset NCIT_C176424 @default.
- NCIT_C174419 inSubset NCIT_C177537 @default.
- NCIT_C174419 inSubset NCIT_C63923 @default.
- NCIT_C174419 type Class @default.
- NCIT_C174419 isDefinedBy ncit.owl @default.
- NCIT_C174419 label "Fidasimtamab" @default.
- NCIT_C174419 subClassOf NCIT_C129821 @default.
- NCIT_C174419 subClassOf NCIT_C129822 @default.
- NCIT_C174419 subClassOf NCIT_C1454 @default.
- NCIT_C174419 subClassOf NCIT_C174419 @default.
- NCIT_C174419 subClassOf NCIT_C1908 @default.
- NCIT_C174419 subClassOf NCIT_C1909 @default.
- NCIT_C174419 subClassOf NCIT_C20401 @default.
- NCIT_C174419 subClassOf NCIT_C274 @default.
- NCIT_C174419 subClassOf NCIT_C28227 @default.
- NCIT_C174419 subClassOf NCIT_C307 @default.
- NCIT_C174419 subClassOf NCIT_C308 @default.