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- NCIT_C174424 IAO_0000115 "An orally bioavailable inhibitor of human DNA methyltransferase 1 (DNMT1), with potential antineoplastic activity. Upon oral administration, DNMT1 inhibitor NTX-301 targets ad binds to DNMT1, thereby inhibiting the activity of DNMT1. This may prevent DNA methylation, induce DNA hypomethylation, and activate tumor suppressor genes silenced by hypermethylation. This may inhibit tumor cell proliferation. DNMT1, a member of the DNA methyltransferase (DNMT) family, plays an important role in maintaining the DNA methylation pattern. Dysregulation of DNMT1 has been associated with a number of cancers." @default.
- NCIT_C174424 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174424 NCIT_NHC0 "C174424" @default.
- NCIT_C174424 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174424 NCIT_P107 "DNMT1 Inhibitor NTX-301" @default.
- NCIT_C174424 NCIT_P108 "DNMT1 Inhibitor NTX-301" @default.
- NCIT_C174424 NCIT_P208 "CL1411982" @default.
- NCIT_C174424 NCIT_P322 "CTRP" @default.
- NCIT_C174424 NCIT_P322 "GDC" @default.
- NCIT_C174424 NCIT_P329 "802300" @default.
- NCIT_C174424 NCIT_P330 "802300" @default.
- NCIT_C174424 NCIT_P375 "DNMT1 Inhibitor NTX-301" @default.
- NCIT_C174424 NCIT_P399 "802300" @default.
- NCIT_C174424 normalizedInformationContent "100" @default.
- NCIT_C174424 referenceCount "1" @default.
- NCIT_C174424 hasExactSynonym "DNMT1 Inhibitor NTX-301" @default.
- NCIT_C174424 hasExactSynonym "NTX 301" @default.
- NCIT_C174424 hasExactSynonym "NTX-301" @default.
- NCIT_C174424 hasExactSynonym "NTX301" @default.
- NCIT_C174424 inSubset NCIT_C116977 @default.
- NCIT_C174424 inSubset NCIT_C116978 @default.
- NCIT_C174424 inSubset NCIT_C128784 @default.
- NCIT_C174424 inSubset NCIT_C157711 @default.
- NCIT_C174424 inSubset NCIT_C157712 @default.
- NCIT_C174424 inSubset NCIT_C176424 @default.
- NCIT_C174424 inSubset NCIT_C177537 @default.
- NCIT_C174424 type Class @default.
- NCIT_C174424 isDefinedBy ncit.owl @default.
- NCIT_C174424 label "DNMT1 Inhibitor NTX-301" @default.
- NCIT_C174424 subClassOf NCIT_C132686 @default.
- NCIT_C174424 subClassOf NCIT_C174424 @default.
- NCIT_C174424 subClassOf NCIT_C1908 @default.
- NCIT_C174424 subClassOf NCIT_C1909 @default.
- NCIT_C174424 subClassOf NCIT_C2083 @default.
- NCIT_C174424 subClassOf NCIT_C274 @default.
- NCIT_C174424 subClassOf NCIT_C471 @default.