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- NCIT_C174469 IAO_0000115 "A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid (MeCOSar) and labeled with the positron emission tomography (PET) tracer copper Cu 64, which may be used to image somatostatin receptor (SSTR)-expressing neuroendocrine tumors (NETs) upon PET. Upon administration of copper Cu 64-MeCOSar-Tyr3-octreotate, the TATE moiety targets and binds to SSTRs, with high affinity for type 2 SSTR, present on the cell membranes of many types of NETs. This allows for visualization of SSTR-positive tumor cells upon PET. TATE is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTRs." @default.
- NCIT_C174469 NCIT_A7 NCIT_C17922 @default.
- NCIT_C174469 NCIT_NHC0 "C174469" @default.
- NCIT_C174469 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174469 NCIT_P107 "Copper Cu 64-MeCOSar-Tyr3-octreotate" @default.
- NCIT_C174469 NCIT_P108 "Copper Cu 64-MeCOSar-Tyr3-octreotate" @default.
- NCIT_C174469 NCIT_P208 "CL1412004" @default.
- NCIT_C174469 NCIT_P319 "UJY48W6ADC" @default.
- NCIT_C174469 NCIT_P322 "CTRP" @default.
- NCIT_C174469 NCIT_P322 "FDA" @default.
- NCIT_C174469 NCIT_P329 "803120" @default.
- NCIT_C174469 NCIT_P330 "803120" @default.
- NCIT_C174469 NCIT_P399 "803120" @default.
- NCIT_C174469 normalizedInformationContent "100" @default.
- NCIT_C174469 referenceCount "1" @default.
- NCIT_C174469 hasExactSynonym "64Cu-SARTATE" @default.
- NCIT_C174469 hasExactSynonym "64Cu-labeled MeCOSar-Tyr3-octreotate" @default.
- NCIT_C174469 hasExactSynonym "Copper 64 SARTATE" @default.
- NCIT_C174469 hasExactSynonym "Copper Cu 64-MeCOSar-Tyr3-octreotate" @default.
- NCIT_C174469 hasExactSynonym "Copper Cu 64-SARTATE" @default.
- NCIT_C174469 hasExactSynonym "Cu-64 SARTATE" @default.
- NCIT_C174469 hasExactSynonym "SARTATE CU-64" @default.
- NCIT_C174469 inSubset NCIT_C116977 @default.
- NCIT_C174469 inSubset NCIT_C116978 @default.
- NCIT_C174469 inSubset NCIT_C176424 @default.
- NCIT_C174469 inSubset NCIT_C63923 @default.
- NCIT_C174469 type Class @default.
- NCIT_C174469 isDefinedBy ncit.owl @default.
- NCIT_C174469 label "Copper Cu 64-MeCOSar-Tyr3-octreotate" @default.
- NCIT_C174469 subClassOf NCIT_C1446 @default.
- NCIT_C174469 subClassOf NCIT_C174469 @default.
- NCIT_C174469 subClassOf NCIT_C1908 @default.
- NCIT_C174469 subClassOf NCIT_C1909 @default.
- NCIT_C174469 subClassOf NCIT_C2124 @default.