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- NCIT_C174517 IAO_0000115 "An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival." @default.
- NCIT_C174517 NCIT_A32 NCIT_C1909 @default.
- NCIT_C174517 NCIT_A7 NCIT_C17297 @default.
- NCIT_C174517 NCIT_NHC0 "C174517" @default.
- NCIT_C174517 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174517 NCIT_P108 "FLT3/FGFR Dual Kinase Inhibitor MAX-40279" @default.
- NCIT_C174517 NCIT_P208 "CL1412016" @default.
- NCIT_C174517 NCIT_P210 "2070931-57-4" @default.
- NCIT_C174517 NCIT_P319 "DL772G3NN7" @default.
- NCIT_C174517 NCIT_P322 "FDA" @default.
- NCIT_C174517 NCIT_P322 "GDC" @default.
- NCIT_C174517 NCIT_P329 "802333" @default.
- NCIT_C174517 NCIT_P330 "802333" @default.
- NCIT_C174517 NCIT_P375 "FLT3/FGFR Dual Kinase Inhibitor MAX-40279" @default.
- NCIT_C174517 NCIT_P399 "802333" @default.
- NCIT_C174517 normalizedInformationContent "100" @default.
- NCIT_C174517 referenceCount "1" @default.
- NCIT_C174517 hasExactSynonym "FLT3/FGFR Dual Kinase Inhibitor MAX-40279" @default.
- NCIT_C174517 hasExactSynonym "FLT3/FGFR Kinase Inhibitor MAX-40279" @default.
- NCIT_C174517 hasExactSynonym "MAX 40279" @default.
- NCIT_C174517 hasExactSynonym "MAX-40279" @default.
- NCIT_C174517 hasExactSynonym "MAX-40279-01" @default.
- NCIT_C174517 hasExactSynonym "MAX40279" @default.
- NCIT_C174517 hasExactSynonym "Max 4" @default.
- NCIT_C174517 inSubset NCIT_C128784 @default.
- NCIT_C174517 inSubset NCIT_C157711 @default.
- NCIT_C174517 inSubset NCIT_C157712 @default.
- NCIT_C174517 inSubset NCIT_C176424 @default.
- NCIT_C174517 inSubset NCIT_C177537 @default.
- NCIT_C174517 inSubset NCIT_C63923 @default.
- NCIT_C174517 type Class @default.
- NCIT_C174517 isDefinedBy ncit.owl @default.
- NCIT_C174517 label "FLT3/FGFR Dual Kinase Inhibitor MAX-40279" @default.
- NCIT_C174517 subClassOf NCIT_C124800 @default.
- NCIT_C174517 subClassOf NCIT_C129824 @default.
- NCIT_C174517 subClassOf NCIT_C129825 @default.
- NCIT_C174517 subClassOf NCIT_C1404 @default.
- NCIT_C174517 subClassOf NCIT_C155727 @default.
- NCIT_C174517 subClassOf NCIT_C163758 @default.
- NCIT_C174517 subClassOf NCIT_C163790 @default.
- NCIT_C174517 subClassOf NCIT_C164035 @default.
- NCIT_C174517 subClassOf NCIT_C174517 @default.
- NCIT_C174517 subClassOf NCIT_C1908 @default.
- NCIT_C174517 subClassOf NCIT_C1909 @default.
- NCIT_C174517 subClassOf NCIT_C1967 @default.
- NCIT_C174517 subClassOf NCIT_C2189 @default.
- NCIT_C174517 subClassOf NCIT_C274 @default.
- NCIT_C174517 subClassOf NCIT_C471 @default.