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- NCIT_C174523 IAO_0000115 "An imaging agent composed of the cyclic arginine-glycine-aspartic acid (cRGD)-based peptide derivative cyclo-(RGDyK) conjugated to the near-infrared (NIR) fluorophore ZW800-1, with potential use as a tumor-selective fluorescent imaging agent. Upon administration of the fluorescent imaging agent cRGD-ZW800-1, the cRGD moiety selectively binds to integrins, including alphaVbeta3, alphaVbeta5 and alphaVbeta6, expressed on tumor cells and tumor-associated vascular endothelium. Upon intraoperative fluorescence imaging, tumor cells and tumor-associated vascular endothelium expressing these integrins can be visualized. Integrins are transmembrane glycoproteins upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis." @default.
- NCIT_C174523 NCIT_NHC0 "C174523" @default.
- NCIT_C174523 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174523 NCIT_P108 "Fluorescent Imaging Agent cRGD-ZW800-1" @default.
- NCIT_C174523 NCIT_P208 "CL1411839" @default.
- NCIT_C174523 NCIT_P329 "802375" @default.
- NCIT_C174523 NCIT_P330 "802375" @default.
- NCIT_C174523 NCIT_P399 "802375" @default.
- NCIT_C174523 normalizedInformationContent "100" @default.
- NCIT_C174523 referenceCount "1" @default.
- NCIT_C174523 hasExactSynonym "Fluorescent Imaging Agent cRGD-ZW800-1" @default.
- NCIT_C174523 hasExactSynonym "cRGD-ZW800-1" @default.
- NCIT_C174523 hasExactSynonym "cyclo-(RGDyK)-ZW800-1" @default.
- NCIT_C174523 inSubset NCIT_C176424 @default.
- NCIT_C174523 type Class @default.
- NCIT_C174523 isDefinedBy ncit.owl @default.
- NCIT_C174523 label "Fluorescent Imaging Agent cRGD-ZW800-1" @default.
- NCIT_C174523 subClassOf NCIT_C174523 @default.
- NCIT_C174523 subClassOf NCIT_C1908 @default.
- NCIT_C174523 subClassOf NCIT_C1966 @default.
- NCIT_C174523 subClassOf NCIT_C45678 @default.
- NCIT_C174523 subClassOf NCIT_C802 @default.