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- NCIT_C174538 IAO_0000115 "A fixed combination of aspirin, a cyclooxygenase inhibitor, and dipyridamole, a phosphodiesterase (PDE) inhibitor, with antiplatelet and antithrombotic activities. Upon oral administration of aspirin/dipyridamole, aspirin binds to and irreversibly inhibits platelet cyclooxygenase, thereby inhibiting thromboxane A2 formation. This prevents platelet aggregation and vasoconstriction. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen." @default.
- NCIT_C174538 NCIT_NHC0 "C174538" @default.
- NCIT_C174538 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174538 NCIT_P108 "Aspirin/Dipyridamole" @default.
- NCIT_C174538 NCIT_P208 "CL1411819" @default.
- NCIT_C174538 NCIT_P210 "87653-67-6" @default.
- NCIT_C174538 normalizedInformationContent "100" @default.
- NCIT_C174538 referenceCount "1" @default.
- NCIT_C174538 hasExactSynonym "Aggrenox" @default.
- NCIT_C174538 hasExactSynonym "Aspirin and Dipyridamole" @default.
- NCIT_C174538 hasExactSynonym "Aspirin-Dipyridamole" @default.
- NCIT_C174538 hasExactSynonym "Aspirin/Dipyridamole" @default.
- NCIT_C174538 hasExactSynonym "Dipyridamole-Aspirin" @default.
- NCIT_C174538 hasExactSynonym "Dipyridamole/Aspirin" @default.
- NCIT_C174538 inSubset NCIT_C173381 @default.
- NCIT_C174538 inSubset NCIT_C173383 @default.
- NCIT_C174538 type Class @default.
- NCIT_C174538 isDefinedBy ncit.owl @default.
- NCIT_C174538 label "Aspirin/Dipyridamole" @default.
- NCIT_C174538 subClassOf NCIT_C1323 @default.
- NCIT_C174538 subClassOf NCIT_C174538 @default.
- NCIT_C174538 subClassOf NCIT_C1908 @default.
- NCIT_C174538 subClassOf NCIT_C1909 @default.
- NCIT_C174538 subClassOf NCIT_C2198 @default.
- NCIT_C174538 subClassOf NCIT_C2356 @default.
- NCIT_C174538 subClassOf NCIT_C241 @default.
- NCIT_C174538 subClassOf NCIT_C257 @default.
- NCIT_C174538 subClassOf NCIT_C471 @default.
- NCIT_C174538 subClassOf NCIT_C744 @default.
- NCIT_C174538 subClassOf NCIT_C78272 @default.