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- NCIT_C174563 IAO_0000115 "A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been transduced with a lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) CD19 that is fused to the intracellular cytoplasmic domain of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (CD3zeta), and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2 specifically target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and causes tumor cell lysis. CD19 is a B-cell-specific cell surface antigen that is overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domain increases human T-cell function, expansion, and survival. Devoid of both ligand binding domains and tyrosine kinase activity, the co-expressed HER2tG both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a trastuzumab-induced antibody dependent cellular cytotoxicity (ADCC) response." @default.
- NCIT_C174563 NCIT_A7 NCIT_C38894 @default.
- NCIT_C174563 NCIT_NHC0 "C174563" @default.
- NCIT_C174563 NCIT_P106 "Cell" @default.
- NCIT_C174563 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174563 NCIT_P107 "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2" @default.
- NCIT_C174563 NCIT_P108 "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2" @default.
- NCIT_C174563 NCIT_P208 "CL1411863" @default.
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- NCIT_C174563 NCIT_P329 "803122" @default.
- NCIT_C174563 NCIT_P330 "803122" @default.
- NCIT_C174563 NCIT_P399 "803122" @default.
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- NCIT_C174563 NCIT_R72 NCIT_C39568 @default.
- NCIT_C174563 normalizedInformationContent "100" @default.
- NCIT_C174563 referenceCount "1" @default.
- NCIT_C174563 hasExactSynonym "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2" @default.
- NCIT_C174563 hasExactSynonym "Autologous CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2" @default.
- NCIT_C174563 hasExactSynonym "SCRI-huCAR19v2" @default.
- NCIT_C174563 inSubset NCIT_C116977 @default.
- NCIT_C174563 inSubset NCIT_C116978 @default.
- NCIT_C174563 inSubset NCIT_C128784 @default.
- NCIT_C174563 inSubset NCIT_C176424 @default.
- NCIT_C174563 type Class @default.
- NCIT_C174563 isDefinedBy ncit.owl @default.
- NCIT_C174563 label "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2" @default.
- NCIT_C174563 subClassOf NCIT_C129820 @default.
- NCIT_C174563 subClassOf NCIT_C129821 @default.
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- NCIT_C174563 subClassOf NCIT_C137999 @default.
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- NCIT_C174563 subClassOf NCIT_C1908 @default.
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- NCIT_C174563 subClassOf NCIT_C1962 @default.
- NCIT_C174563 subClassOf NCIT_C200766 @default.
- NCIT_C174563 subClassOf NCIT_C274 @default.
- NCIT_C174563 subClassOf NCIT_C28681 @default.
- NCIT_C174563 subClassOf NCIT_C307 @default.
- NCIT_C174563 subClassOf NCIT_C308 @default.