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- NCIT_C174672 IAO_0000115 "A human immunoglobulin G2 (IgG2) monoclonal antibody directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9), that can be used in the treatment of hypercholesterolemia. Upon administration, evolocumab targets, binds to and inhibits the activity of PCSK9. This prevents binding of PCSK9 to low-density lipoprotein receptor (LDLR) on hepatocytes and prevents its degradation. This increases LDLR on hepatocytes and increases the liver's ability to remove LDL cholesterol (LDL-C) from the blood, thereby lowering LDL-C levels. PCSK9 binds to LDLR on the surface of hepatocytes to promote LDLR degradation within the liver." @default.
- NCIT_C174672 NCIT_NHC0 "C174672" @default.
- NCIT_C174672 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C174672 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174672 NCIT_P108 "Evolocumab" @default.
- NCIT_C174672 NCIT_P208 "CL1412172" @default.
- NCIT_C174672 NCIT_P210 "1256937-27-5" @default.
- NCIT_C174672 NCIT_P319 "LKC0U3A8NJ" @default.
- NCIT_C174672 NCIT_P322 "FDA" @default.
- NCIT_C174672 NCIT_P399 "808340" @default.
- NCIT_C174672 NCIT_R124 NCIT_C17710 @default.
- NCIT_C174672 NCIT_R124 NCIT_C17828 @default.
- NCIT_C174672 NCIT_R124 NCIT_C18219 @default.
- NCIT_C174672 NCIT_R124 NCIT_C19986 @default.
- NCIT_C174672 NCIT_R124 NCIT_C40474 @default.
- NCIT_C174672 normalizedInformationContent "100" @default.
- NCIT_C174672 referenceCount "1" @default.
- NCIT_C174672 hasExactSynonym "AMG 145" @default.
- NCIT_C174672 hasExactSynonym "AMG-145" @default.
- NCIT_C174672 hasExactSynonym "AMG145" @default.
- NCIT_C174672 hasExactSynonym "EVOLOCUMAB" @default.
- NCIT_C174672 hasExactSynonym "Evolocumab" @default.
- NCIT_C174672 hasExactSynonym "Repatha" @default.
- NCIT_C174672 inSubset NCIT_C176424 @default.
- NCIT_C174672 inSubset NCIT_C63923 @default.
- NCIT_C174672 type Class @default.
- NCIT_C174672 isDefinedBy ncit.owl @default.
- NCIT_C174672 label "Evolocumab" @default.
- NCIT_C174672 subClassOf NCIT_C174672 @default.
- NCIT_C174672 subClassOf NCIT_C190797 @default.
- NCIT_C174672 subClassOf NCIT_C1908 @default.
- NCIT_C174672 subClassOf NCIT_C1909 @default.
- NCIT_C174672 subClassOf NCIT_C20401 @default.
- NCIT_C174672 subClassOf NCIT_C29703 @default.
- NCIT_C174672 subClassOf NCIT_C307 @default.
- NCIT_C174672 subClassOf NCIT_C308 @default.
- NCIT_C174672 subClassOf NCIT_C78276 @default.