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- NCIT_C1748 IAO_0000115 "Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis." @default.
- NCIT_C1748 NCIT_NHC0 "C1748" @default.
- NCIT_C1748 NCIT_P106 "Chemical Viewed Functionally" @default.
- NCIT_C1748 NCIT_P108 "Topoisomerase Inhibitor" @default.
- NCIT_C1748 NCIT_P207 "C0598317" @default.
- NCIT_C1748 NCIT_P325 "A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer." @default.
- NCIT_C1748 NCIT_P366 "Topoisomerase_Inhibitor" @default.
- NCIT_C1748 normalizedInformationContent "50.445045810989633" @default.
- NCIT_C1748 referenceCount "1788" @default.
- NCIT_C1748 hasExactSynonym "DNA Topoisomerase Inhibitors" @default.
- NCIT_C1748 hasExactSynonym "Topoisomerase Inhibitor" @default.
- NCIT_C1748 hasExactSynonym "Topoisomerase Inhibitors" @default.
- NCIT_C1748 hasExactSynonym "topoisomerase inhibitor" @default.
- NCIT_C1748 type Class @default.
- NCIT_C1748 isDefinedBy ncit.owl @default.
- NCIT_C1748 label "Topoisomerase Inhibitor" @default.
- NCIT_C1748 subClassOf NCIT_C129824 @default.
- NCIT_C1748 subClassOf NCIT_C129825 @default.
- NCIT_C1748 subClassOf NCIT_C1748 @default.
- NCIT_C1748 subClassOf NCIT_C1908 @default.
- NCIT_C1748 subClassOf NCIT_C1909 @default.
- NCIT_C1748 subClassOf NCIT_C2189 @default.
- NCIT_C1748 subClassOf NCIT_C274 @default.
- NCIT_C1748 subClassOf NCIT_C471 @default.