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- NCIT_C174886 IAO_0000115 "The sodium salt form of lifitegrast, a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 (LFA-1) antagonist, that can be used as an ophthalmic solution for the treatment of dry eye disease (DED; keratoconjunctivitis sicca; dry eye syndrome). Upon ocular administration and although the exact mechanism of action of lifitegrast in DED is not fully known, lifitegrast targets and binds to the integrin LFA-1, a cell surface protein found on leukocytes. This prevents the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). As ICAM-1 may be overexpressed in corneal and conjunctival tissues in DED, the blockage of the LFA-1/ICAM-1 interaction by lifitegrast may inhibit T-cell adhesion to ICAM-1 and may abrogate the formation of an immunological synapse. This may prevent T-cell proliferation, activation and migration and the release of pro-inflammatory cytokines in the corneal and conjunctival tissues. This may reduce inflammation, protect the corneal surface from inflammatory-mediated damage and reduce the symptoms of DED." @default.
- NCIT_C174886 NCIT_NHC0 "C174886" @default.
- NCIT_C174886 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C174886 NCIT_P108 "Lifitegrast Sodium" @default.
- NCIT_C174886 NCIT_P208 "CL1412160" @default.
- NCIT_C174886 NCIT_P210 "1119276-80-0" @default.
- NCIT_C174886 NCIT_P319 "QG18FLP1KP" @default.
- NCIT_C174886 NCIT_P322 "FDA" @default.
- NCIT_C174886 normalizedInformationContent "100" @default.
- NCIT_C174886 referenceCount "1" @default.
- NCIT_C174886 hasExactSynonym "LIFITEGRAST SODIUM" @default.
- NCIT_C174886 hasExactSynonym "Lifitegrast Sodium" @default.
- NCIT_C174886 inSubset NCIT_C63923 @default.
- NCIT_C174886 type Class @default.
- NCIT_C174886 isDefinedBy ncit.owl @default.
- NCIT_C174886 label "Lifitegrast Sodium" @default.
- NCIT_C174886 subClassOf NCIT_C174886 @default.
- NCIT_C174886 subClassOf NCIT_C1908 @default.
- NCIT_C174886 subClassOf NCIT_C1909 @default.
- NCIT_C174886 subClassOf NCIT_C78283 @default.