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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C17489> ?p ?o ?g. }

• NCIT_C17489 IAO_0000115 "Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated immune responses." @default.
• NCIT_C17489 NCIT_NHC0 "C17489" @default.
• NCIT_C17489 NCIT_P100 "123890" @default.
• NCIT_C17489 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
• NCIT_C17489 NCIT_P106 "Immunologic Factor" @default.
• NCIT_C17489 NCIT_P106 "Receptor" @default.
• NCIT_C17489 NCIT_P107 "Cytotoxic T-Lymphocyte Protein 4" @default.
• NCIT_C17489 NCIT_P108 "Cytotoxic T-Lymphocyte Protein 4" @default.
• NCIT_C17489 NCIT_P207 "C0111208" @default.
• NCIT_C17489 NCIT_P322 "CTRP" @default.
• NCIT_C17489 NCIT_P366 "Cytotoxic_T-Lymphocyte-Associated_Protein-4" @default.
• NCIT_C17489 NCIT_P93 "P16410" @default.
• NCIT_C17489 NCIT_P98 "CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells that shares significant homology and ligand specificity with CD28. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation and CTLA-4 binds to B7 with a greater affinity. B7 antigen presenting cells regulate T-cell activation by delivering stimulatory signals through CD28 and inhibitory signals through CTLA-4. A CTLA-4 splice variant with a deleted transmembrane segment (soluble CTLA-4 or sCTLA-4) is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. (OMIM)" @default.
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