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- NCIT_C175056 IAO_0000115 "The mesylate salt form of belumosudil, an orally bioavailable inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II), with potential immunomodulating activity. Upon oral administration, belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signal transduction pathways and modulates various pro- and anti-inflammatory immune cell responses through the regulation of signal transducer and activator of transcription 3 and 5 (STAT3/STAT5) phosphorylation. This downregulates pro-inflammatory Th17 cells and increases regulatory T (Treg) cells. Belumosudil also inhibits ROCK2-mediated fibrotic processes, including stress fiber formation, myofibroblast activation and pro-fibrotic gene transcription. ROCK2 is upregulated in various diseases, including various fibrotic, neurodegenerative and autoimmune diseases." @default.
- NCIT_C175056 NCIT_A7 NCIT_C178173 @default.
- NCIT_C175056 NCIT_NHC0 "C175056" @default.
- NCIT_C175056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175056 NCIT_P107 "Belumosudil Mesylate" @default.
- NCIT_C175056 NCIT_P108 "Belumosudil Mesylate" @default.
- NCIT_C175056 NCIT_P208 "CL1412310" @default.
- NCIT_C175056 NCIT_P210 "2109704-99-4" @default.
- NCIT_C175056 NCIT_P302 "for adult and pediatric patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic therapy." @default.
- NCIT_C175056 NCIT_P319 "6MX7XE1M0U" @default.
- NCIT_C175056 NCIT_P322 "CTRP" @default.
- NCIT_C175056 NCIT_P322 "FDA" @default.
- NCIT_C175056 NCIT_P399 "806249" @default.
- NCIT_C175056 normalizedInformationContent "100" @default.
- NCIT_C175056 referenceCount "1" @default.
- NCIT_C175056 hasExactSynonym "2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(propan-2-yl)acetamide Methanesulfonate (1:1)" @default.
- NCIT_C175056 hasExactSynonym "Acetamide, 2-(3-(4-(1H-indazol-5-ylamino)-2-quinazolinyl)phenoxy)-N-(1-methylethyl)-, Methanesulfonate (1:1)" @default.
- NCIT_C175056 hasExactSynonym "BELUMOSUDIL MESYLATE" @default.
- NCIT_C175056 hasExactSynonym "Belumosudil Mesylate" @default.
- NCIT_C175056 hasExactSynonym "KD025 Mesylate" @default.
- NCIT_C175056 hasExactSynonym "Rezurock" @default.
- NCIT_C175056 inSubset NCIT_C116977 @default.
- NCIT_C175056 inSubset NCIT_C116978 @default.
- NCIT_C175056 inSubset NCIT_C176424 @default.
- NCIT_C175056 inSubset NCIT_C63923 @default.
- NCIT_C175056 type Class @default.
- NCIT_C175056 isDefinedBy ncit.owl @default.
- NCIT_C175056 label "Belumosudil Mesylate" @default.
- NCIT_C175056 subClassOf NCIT_C1404 @default.
- NCIT_C175056 subClassOf NCIT_C175056 @default.
- NCIT_C175056 subClassOf NCIT_C1908 @default.
- NCIT_C175056 subClassOf NCIT_C1909 @default.
- NCIT_C175056 subClassOf NCIT_C471 @default.
- NCIT_C175056 subClassOf NCIT_C61074 @default.