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- NCIT_C175088 IAO_0000115 "The phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Upon administration, infigratinib selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of angiogenesis and cell proliferation, and the induction of cell death in tumors with activating FGFR amplifications, mutations, or fusions. FGFRs are a family of receptor tyrosine kinases that are involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival. Activating FGFR amplifications, mutations, or fusions occur in various cancer cell types." @default.
- NCIT_C175088 NCIT_A7 NCIT_C17411 @default.
- NCIT_C175088 NCIT_NHC0 "C175088" @default.
- NCIT_C175088 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175088 NCIT_P107 "Infigratinib Phosphate" @default.
- NCIT_C175088 NCIT_P108 "Infigratinib Phosphate" @default.
- NCIT_C175088 NCIT_P208 "CL1412340" @default.
- NCIT_C175088 NCIT_P210 "1310746-10-1" @default.
- NCIT_C175088 NCIT_P302 "unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement" @default.
- NCIT_C175088 NCIT_P319 "58BH47BV6S" @default.
- NCIT_C175088 NCIT_P322 "CTRP" @default.
- NCIT_C175088 NCIT_P322 "FDA" @default.
- NCIT_C175088 NCIT_P399 "659161" @default.
- NCIT_C175088 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C175088 referenceCount "2" @default.
- NCIT_C175088 hasExactSynonym "INFIGRATINIB PHOSPHATE" @default.
- NCIT_C175088 hasExactSynonym "Infigratinib Phosphate" @default.
- NCIT_C175088 hasExactSynonym "N'-(2,6-Dichloro-3,5-dimethoxyphenyl)-N-(6-(4-(4-ethylpiperazin-1-yl)anilino)pyrimidin-4-yl)-N-methylurea Phosphate (1:1)" @default.
- NCIT_C175088 hasExactSynonym "Truseltiq" @default.
- NCIT_C175088 inSubset NCIT_C116977 @default.
- NCIT_C175088 inSubset NCIT_C116978 @default.
- NCIT_C175088 inSubset NCIT_C128784 @default.
- NCIT_C175088 inSubset NCIT_C176424 @default.
- NCIT_C175088 inSubset NCIT_C63923 @default.
- NCIT_C175088 type Class @default.
- NCIT_C175088 isDefinedBy ncit.owl @default.
- NCIT_C175088 label "Infigratinib Phosphate" @default.
- NCIT_C175088 subClassOf NCIT_C129824 @default.
- NCIT_C175088 subClassOf NCIT_C129825 @default.
- NCIT_C175088 subClassOf NCIT_C1404 @default.
- NCIT_C175088 subClassOf NCIT_C155727 @default.
- NCIT_C175088 subClassOf NCIT_C163758 @default.
- NCIT_C175088 subClassOf NCIT_C164035 @default.
- NCIT_C175088 subClassOf NCIT_C175088 @default.
- NCIT_C175088 subClassOf NCIT_C1908 @default.
- NCIT_C175088 subClassOf NCIT_C1909 @default.
- NCIT_C175088 subClassOf NCIT_C1967 @default.
- NCIT_C175088 subClassOf NCIT_C2189 @default.
- NCIT_C175088 subClassOf NCIT_C274 @default.
- NCIT_C175088 subClassOf NCIT_C471 @default.