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- NCIT_C175198 IAO_0000115 "The besylate ester form of remimazolam, a short-acting benzodiazepine derivative that is structurally related to midazolam, with sedative-hypnotic activity. Upon administration, remimazolam targets and binds to a specific site on the gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability." @default.
- NCIT_C175198 NCIT_A6 NCIT_C152187 @default.
- NCIT_C175198 NCIT_NHC0 "C175198" @default.
- NCIT_C175198 NCIT_P106 "Organic Chemical" @default.
- NCIT_C175198 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175198 NCIT_P108 "Remimazolam Besylate" @default.
- NCIT_C175198 NCIT_P208 "CL1636311" @default.
- NCIT_C175198 NCIT_P210 "1001415-66-2" @default.
- NCIT_C175198 NCIT_P319 "280XQ6482H" @default.
- NCIT_C175198 NCIT_P322 "FDA" @default.
- NCIT_C175198 NCIT_P399 "811462" @default.
- NCIT_C175198 normalizedInformationContent "100" @default.
- NCIT_C175198 referenceCount "1" @default.
- NCIT_C175198 hasExactSynonym "REMIMAZOLAM BESYLATE" @default.
- NCIT_C175198 hasExactSynonym "Remimazolam Benzenesulfonate" @default.
- NCIT_C175198 hasExactSynonym "Remimazolam Besylate" @default.
- NCIT_C175198 inSubset NCIT_C63923 @default.
- NCIT_C175198 type Class @default.
- NCIT_C175198 isDefinedBy ncit.owl @default.
- NCIT_C175198 label "Remimazolam Besylate" @default.
- NCIT_C175198 subClassOf NCIT_C1012 @default.
- NCIT_C175198 subClassOf NCIT_C175198 @default.
- NCIT_C175198 subClassOf NCIT_C1908 @default.
- NCIT_C175198 subClassOf NCIT_C1909 @default.
- NCIT_C175198 subClassOf NCIT_C28197 @default.
- NCIT_C175198 subClassOf NCIT_C29756 @default.
- NCIT_C175198 subClassOf NCIT_C78272 @default.