Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C175251> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C175251 IAO_0000115 "An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity. Upon administration, CDK2 inhibitor PF-07104091 selectively targets, binds to and inhibits the activity of CDK2. This may lead to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation and are frequently overexpressed in tumor cells. CDK2/cyclin E complex plays an important role in retinoblastoma (Rb) protein phosphorylation and the G1-S phase cell cycle transition. CDK2/cyclin A complex plays an important role in DNA synthesis in S phase and the activation of CDK1/cyclin B for the G2-M phase cell cycle transition." @default.
- NCIT_C175251 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175251 NCIT_A7 NCIT_C25842 @default.
- NCIT_C175251 NCIT_NHC0 "C175251" @default.
- NCIT_C175251 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175251 NCIT_P107 "CDK2 Inhibitor PF-07104091" @default.
- NCIT_C175251 NCIT_P108 "CDK2 Inhibitor PF-07104091" @default.
- NCIT_C175251 NCIT_P208 "CL1412749" @default.
- NCIT_C175251 NCIT_P322 "CTRP" @default.
- NCIT_C175251 NCIT_P322 "GDC" @default.
- NCIT_C175251 NCIT_P329 "803259" @default.
- NCIT_C175251 NCIT_P330 "803259" @default.
- NCIT_C175251 NCIT_P375 "CDK2 Inhibitor PF-07104091" @default.
- NCIT_C175251 NCIT_P399 "803259" @default.
- NCIT_C175251 normalizedInformationContent "100" @default.
- NCIT_C175251 referenceCount "1" @default.
- NCIT_C175251 hasExactSynonym "CDK2 Inhibitor PF-07104091" @default.
- NCIT_C175251 hasExactSynonym "Cyclin-dependent Kinase 2 Inhibitor PF-07104091" @default.
- NCIT_C175251 hasExactSynonym "PF 07104091" @default.
- NCIT_C175251 hasExactSynonym "PF-07104091" @default.
- NCIT_C175251 hasExactSynonym "PF07104091" @default.
- NCIT_C175251 inSubset NCIT_C116977 @default.
- NCIT_C175251 inSubset NCIT_C116978 @default.
- NCIT_C175251 inSubset NCIT_C128784 @default.
- NCIT_C175251 inSubset NCIT_C157711 @default.
- NCIT_C175251 inSubset NCIT_C157712 @default.
- NCIT_C175251 inSubset NCIT_C176424 @default.
- NCIT_C175251 inSubset NCIT_C177537 @default.
- NCIT_C175251 type Class @default.
- NCIT_C175251 isDefinedBy ncit.owl @default.
- NCIT_C175251 label "CDK2 Inhibitor PF-07104091" @default.
- NCIT_C175251 subClassOf NCIT_C129824 @default.
- NCIT_C175251 subClassOf NCIT_C129825 @default.
- NCIT_C175251 subClassOf NCIT_C1404 @default.
- NCIT_C175251 subClassOf NCIT_C163758 @default.
- NCIT_C175251 subClassOf NCIT_C175251 @default.
- NCIT_C175251 subClassOf NCIT_C1908 @default.
- NCIT_C175251 subClassOf NCIT_C1909 @default.
- NCIT_C175251 subClassOf NCIT_C200052 @default.
- NCIT_C175251 subClassOf NCIT_C2185 @default.
- NCIT_C175251 subClassOf NCIT_C2189 @default.
- NCIT_C175251 subClassOf NCIT_C274 @default.
- NCIT_C175251 subClassOf NCIT_C471 @default.
- NCIT_C175251 subClassOf NCIT_C61074 @default.