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- NCIT_C175305 IAO_0000115 "A fixed combination of naltrexone hydrochloride, an opioid antagonist, and bupropion hydrochloride, an aminoketone antidepressant and a weak inhibitor of the neuronal reuptake of dopamine and norepinephrine, that may be used for appetite regulation, weight management and weight loss. Upon oral administration of naltrexone hydrochloride/bupropion hydrochloride, naltrexone binds to and blocks the various opioid receptors in the central nervous system. Bupropion inhibits neuronal reuptake of dopamine and norepinephrine, thereby increasing the level of these neurotransmitters. Bupropion may also have a direct effect on the hypothalamus, the appetite regulatory center. These actions may block the rewarding aspects of food and reduce appetite and food cravings, and contribute to weight loss." @default.
- NCIT_C175305 NCIT_NHC0 "C175305" @default.
- NCIT_C175305 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175305 NCIT_P107 "Naltrexone Hydrochloride/Bupropion Hydrochloride" @default.
- NCIT_C175305 NCIT_P108 "Naltrexone Hydrochloride/Bupropion Hydrochloride" @default.
- NCIT_C175305 NCIT_P208 "CL1412648" @default.
- NCIT_C175305 NCIT_P322 "CTRP" @default.
- NCIT_C175305 NCIT_P329 "803274" @default.
- NCIT_C175305 NCIT_P330 "803274" @default.
- NCIT_C175305 NCIT_P399 "803274" @default.
- NCIT_C175305 normalizedInformationContent "100" @default.
- NCIT_C175305 referenceCount "1" @default.
- NCIT_C175305 hasExactSynonym "Bupropion Hydrochloride-Naltrexone Hydrochloride" @default.
- NCIT_C175305 hasExactSynonym "Bupropion Hydrochloride/Naltrexone Hydrochloride" @default.
- NCIT_C175305 hasExactSynonym "Contrave" @default.
- NCIT_C175305 hasExactSynonym "Naltrexone Hydrochloride-Bupropion Hydrochloride" @default.
- NCIT_C175305 hasExactSynonym "Naltrexone Hydrochloride/Bupropion Hydrochloride" @default.
- NCIT_C175305 inSubset NCIT_C116977 @default.
- NCIT_C175305 inSubset NCIT_C116978 @default.
- NCIT_C175305 inSubset NCIT_C176424 @default.
- NCIT_C175305 type Class @default.
- NCIT_C175305 isDefinedBy ncit.owl @default.
- NCIT_C175305 label "Naltrexone Hydrochloride/Bupropion Hydrochloride" @default.
- NCIT_C175305 subClassOf NCIT_C175305 @default.
- NCIT_C175305 subClassOf NCIT_C1908 @default.
- NCIT_C175305 subClassOf NCIT_C1909 @default.
- NCIT_C175305 subClassOf NCIT_C265 @default.
- NCIT_C175305 subClassOf NCIT_C681 @default.
- NCIT_C175305 subClassOf NCIT_C78272 @default.