Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C175380> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- NCIT_C175380 IAO_0000115 "An orally bioavailable activator of pyruvate kinase M2 isoform (PKM2), with potential immunomodulating and antineoplastic activities. Upon oral administration, PKM2 activator TP-1454 locks PKM2 into the active tetrameric form. This may prevent the production of glycolytic intermediates by the less active dimer form of PKM2, depleting the supply of glycolytic intermediates which are needed for tumor cell growth. This may also inhibit immune suppression mediated by the dimer form of PKM2. Altogether, this may slow tumor cell growth and enhance anti-tumor immune responses, thereby inhibiting tumor cell proliferation. PKM2, the predominant PK isoform found in tumor cells, is responsible for catalyzing the last step of glycolysis. PKM2 plays a critical role in the metabolic changes observed in cancer and immune cells and establishes a metabolic advantage for tumor cells over the tumor immune microenvironment." @default.
- NCIT_C175380 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175380 NCIT_A7 NCIT_C74443 @default.
- NCIT_C175380 NCIT_NHC0 "C175380" @default.
- NCIT_C175380 NCIT_P106 "Organic Chemical" @default.
- NCIT_C175380 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175380 NCIT_P107 "Pyruvate Kinase M2 Isoform Activator TP-1454" @default.
- NCIT_C175380 NCIT_P108 "Pyruvate Kinase M2 Isoform Activator TP-1454" @default.
- NCIT_C175380 NCIT_P208 "CL1412698" @default.
- NCIT_C175380 NCIT_P322 "CTRP" @default.
- NCIT_C175380 NCIT_P322 "GDC" @default.
- NCIT_C175380 NCIT_P329 "803280" @default.
- NCIT_C175380 NCIT_P330 "803280" @default.
- NCIT_C175380 NCIT_P375 "Pyruvate Kinase M2 Isoform Activator TP-1454" @default.
- NCIT_C175380 NCIT_P399 "803280" @default.
- NCIT_C175380 normalizedInformationContent "100" @default.
- NCIT_C175380 referenceCount "1" @default.
- NCIT_C175380 hasExactSynonym "PKM2 Activator TP-1454" @default.
- NCIT_C175380 hasExactSynonym "Pyruvate Kinase M2 Isoform Activator TP-1454" @default.
- NCIT_C175380 hasExactSynonym "TP 1454" @default.
- NCIT_C175380 hasExactSynonym "TP-1454" @default.
- NCIT_C175380 hasExactSynonym "TP1454" @default.
- NCIT_C175380 inSubset NCIT_C116977 @default.
- NCIT_C175380 inSubset NCIT_C116978 @default.
- NCIT_C175380 inSubset NCIT_C128784 @default.
- NCIT_C175380 inSubset NCIT_C157711 @default.
- NCIT_C175380 inSubset NCIT_C157712 @default.
- NCIT_C175380 inSubset NCIT_C176424 @default.
- NCIT_C175380 inSubset NCIT_C177537 @default.
- NCIT_C175380 type Class @default.
- NCIT_C175380 isDefinedBy ncit.owl @default.
- NCIT_C175380 label "Pyruvate Kinase M2 Isoform Activator TP-1454" @default.
- NCIT_C175380 subClassOf NCIT_C129820 @default.
- NCIT_C175380 subClassOf NCIT_C175380 @default.
- NCIT_C175380 subClassOf NCIT_C177430 @default.
- NCIT_C175380 subClassOf NCIT_C1908 @default.
- NCIT_C175380 subClassOf NCIT_C1909 @default.
- NCIT_C175380 subClassOf NCIT_C274 @default.
- NCIT_C175380 subClassOf NCIT_C308 @default.