Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C175389> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- NCIT_C175389 IAO_0000115 "A radioimmunoconjugate composed of pembrolizumab, a humanized monoclonal immunoglobulin (Ig) G4 antibody directed against the human cell surface receptor programmed cell death 1 (PD-1; PDCD1; CD279; programmed cell death-1), conjugated with the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) and labeled with the radioisotope copper Cu 64, with potential diagnostic properties upon positron emission tomography (PET) imaging. Upon administration, the monoclonal antibody moiety of copper Cu 64-DOTA-pembrolizumab specifically binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T-cells, and blocks the binding to and activation of PD-1 by its ligands. Upon PET imaging, PD-1-expressing T-cells, as well as pembrolizumab biodistribution, can be visualized and the expected response to treatment with pembrolizumab, as well as selection of patients that would respond to pembrolizumab, can be assessed. The ligands for PD-1 include programmed cell death-1 ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death-1 ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity." @default.
- NCIT_C175389 NCIT_A7 NCIT_C94697 @default.
- NCIT_C175389 NCIT_NHC0 "C175389" @default.
- NCIT_C175389 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175389 NCIT_P107 "Copper Cu 64-DOTA-pembrolizumab" @default.
- NCIT_C175389 NCIT_P108 "Copper Cu 64-DOTA-pembrolizumab" @default.
- NCIT_C175389 NCIT_P208 "CL1412691" @default.
- NCIT_C175389 NCIT_P322 "CTRP" @default.
- NCIT_C175389 NCIT_P329 "803282" @default.
- NCIT_C175389 NCIT_P330 "803282" @default.
- NCIT_C175389 NCIT_P399 "803282" @default.
- NCIT_C175389 normalizedInformationContent "100" @default.
- NCIT_C175389 referenceCount "1" @default.
- NCIT_C175389 hasExactSynonym "64Cu-DOTA-pembrolizumab" @default.
- NCIT_C175389 hasExactSynonym "64Cu-labeled Pembrolizumab" @default.
- NCIT_C175389 hasExactSynonym "64Cu-pembrolizumab" @default.
- NCIT_C175389 hasExactSynonym "Copper Cu 64 Pembrolizumab" @default.
- NCIT_C175389 hasExactSynonym "Copper Cu 64-DOTA-pembrolizumab" @default.
- NCIT_C175389 inSubset NCIT_C116977 @default.
- NCIT_C175389 inSubset NCIT_C116978 @default.
- NCIT_C175389 inSubset NCIT_C176424 @default.
- NCIT_C175389 type Class @default.
- NCIT_C175389 isDefinedBy ncit.owl @default.
- NCIT_C175389 label "Copper Cu 64-DOTA-pembrolizumab" @default.
- NCIT_C175389 subClassOf NCIT_C1446 @default.
- NCIT_C175389 subClassOf NCIT_C1511 @default.
- NCIT_C175389 subClassOf NCIT_C1512 @default.
- NCIT_C175389 subClassOf NCIT_C175389 @default.
- NCIT_C175389 subClassOf NCIT_C1908 @default.
- NCIT_C175389 subClassOf NCIT_C1909 @default.
- NCIT_C175389 subClassOf NCIT_C2124 @default.
- NCIT_C175389 subClassOf NCIT_C307 @default.
- NCIT_C175389 subClassOf NCIT_C308 @default.