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- NCIT_C175458 IAO_0000115 "A preparation of autologous T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A) linked to the CD28 co-stimulatory signaling domain, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CLL1-CAR-CD28-expressing T-lymphocytes specifically target and bind to CLL1-expressing tumor cells. This induces selective toxicity in tumor cells that express the CLL1 antigen. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies." @default.
- NCIT_C175458 NCIT_NHC0 "C175458" @default.
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- NCIT_C175458 NCIT_P108 "Autologous CLL1-CAR-CD28-expressing T-lymphocytes" @default.
- NCIT_C175458 NCIT_P208 "CL1412858" @default.
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- NCIT_C175458 hasExactSynonym "Autologous Anti-CLL-1 CAR T Cells" @default.
- NCIT_C175458 hasExactSynonym "Autologous CLL-1.CAR T Cells" @default.
- NCIT_C175458 hasExactSynonym "Autologous CLL1-CAR-CD28-expressing T-lymphocytes" @default.
- NCIT_C175458 hasExactSynonym "Autologous CLL1-specific CAR T-lymphocytes" @default.
- NCIT_C175458 hasExactSynonym "Autologous CLL1-targeted CAR T Cells" @default.
- NCIT_C175458 inSubset NCIT_C128784 @default.
- NCIT_C175458 inSubset NCIT_C176424 @default.
- NCIT_C175458 type Class @default.
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- NCIT_C175458 label "Autologous CLL1-CAR-CD28-expressing T-lymphocytes" @default.
- NCIT_C175458 subClassOf NCIT_C129820 @default.
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