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NCIT_C17546 IAO_0000115 "Transcription factor E2F1 (437 aa, ~47 kDa) is encoded by the human E2F1 gene. This protein is involved in the regulation of apoptosis, gene transcription, cell cycle progression and cell proliferation." @default.
NCIT_C17546 NCIT_NHC0 "C17546" @default.
NCIT_C17546 NCIT_P100 "189971" @default.
NCIT_C17546 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
NCIT_C17546 NCIT_P107 "Transcription Factor E2F1" @default.
NCIT_C17546 NCIT_P108 "Transcription Factor E2F1" @default.
NCIT_C17546 NCIT_P207 "C1506928" @default.
NCIT_C17546 NCIT_P322 "CTRP" @default.
NCIT_C17546 NCIT_P366 "E2F_Transcription_Factor-1" @default.
NCIT_C17546 NCIT_P93 "Q01094" @default.
NCIT_C17546 NCIT_P98 "Transcription factor E2F1 binds DNA cooperatively with Dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. It activates p53 and p73 gene expression. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner by accumulation of p73 or by a death receptor-dependent mechanism via down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB/E2F repression mediates G1 arrest triggered by TGFB, by p16(INK4A), and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. (OMIM and UniProt)" @default.
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NCIT_C17546 normalizedInformationContent "95.413332725061409" @default.
NCIT_C17546 referenceCount "2" @default.
NCIT_C17546 hasExactSynonym "E2F Transcription Factor 1" @default.
NCIT_C17546 hasExactSynonym "E2F-1" @default.
NCIT_C17546 hasExactSynonym "E2F1" @default.
NCIT_C17546 hasExactSynonym "PBR3" @default.
NCIT_C17546 hasExactSynonym "PRB-Binding Protein E2F-1" @default.
NCIT_C17546 hasExactSynonym "RBAP-1" @default.