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- NCIT_C175469 IAO_0000115 "An intravenous formulation composed of a phospholipid suspension of nanoparticles containing the synthetic retinoid derivative fenretinide, with potential antineoplastic activity. Upon intravenous administration, fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in susceptible tumor cell types. Fenretinide also binds to and inhibits the activity of mammalian target of rapamycin (mTOR), which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Independent of RAR activation and mTOR inhibition, this agent may also modulate gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS)." @default.
- NCIT_C175469 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175469 NCIT_NHC0 "C175469" @default.
- NCIT_C175469 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175469 NCIT_P108 "Fenretinide Phospholipid Suspension ST-001" @default.
- NCIT_C175469 NCIT_P208 "CL1412852" @default.
- NCIT_C175469 NCIT_P322 "GDC" @default.
- NCIT_C175469 NCIT_P329 "802915" @default.
- NCIT_C175469 NCIT_P330 "802915" @default.
- NCIT_C175469 NCIT_P375 "Fenretinide Phospholipid Suspension ST-001" @default.
- NCIT_C175469 NCIT_P399 "802915" @default.
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- NCIT_C175469 normalizedInformationContent "100" @default.
- NCIT_C175469 referenceCount "1" @default.
- NCIT_C175469 hasExactSynonym "Fenretinide Phospholipid Suspension ST-001" @default.
- NCIT_C175469 hasExactSynonym "ST 001" @default.
- NCIT_C175469 hasExactSynonym "ST-001" @default.
- NCIT_C175469 hasExactSynonym "ST001" @default.
- NCIT_C175469 hasExactSynonym "nanoFenretinide ST-001" @default.
- NCIT_C175469 inSubset NCIT_C128784 @default.
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- NCIT_C175469 type Class @default.
- NCIT_C175469 isDefinedBy ncit.owl @default.
- NCIT_C175469 label "Fenretinide Phospholipid Suspension ST-001" @default.
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