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- NCIT_C175473 IAO_0000115 "A genetically engineered oncolytic herpes simplex virus type 1 (oHSV-1) expressing the human immunostimulating cytokine interleukin-12 (IL-12) and an antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intratumoral administration, oHSV-1 expressing IL-12 and anti-PD-1 antibody T3011 infects and replicates in tumor cells causing viral-mediated tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells. Tumor antigens released from the lysed tumor cells also activate the immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells. In addition, oHSV-1 expressing IL-12 and anti-PD-1 antibody T3011 promotes the secretion of IL-12 and anti-PD-1 antibody by the tumor cells. IL-12 promotes the activation of natural killer cells, which induces both the secretion of interferon-gamma and a cytotoxic T-lymphocyte (CTL) response against the tumor cells. This results in both immune-mediated tumor cell death and further inhibition of tumor cell proliferation. Anti-PD-1 antibody targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." @default.
- NCIT_C175473 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175473 NCIT_NHC0 "C175473" @default.
- NCIT_C175473 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175473 NCIT_P107 "Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 NCIT_P108 "Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 NCIT_P208 "CL1412848" @default.
- NCIT_C175473 NCIT_P322 "CTRP" @default.
- NCIT_C175473 NCIT_P322 "GDC" @default.
- NCIT_C175473 NCIT_P329 "802928" @default.
- NCIT_C175473 NCIT_P330 "802928" @default.
- NCIT_C175473 NCIT_P375 "Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 NCIT_P399 "802928" @default.
- NCIT_C175473 normalizedInformationContent "100" @default.
- NCIT_C175473 referenceCount "1" @default.
- NCIT_C175473 hasExactSynonym "MVR-T3011" @default.
- NCIT_C175473 hasExactSynonym "Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 hasExactSynonym "Oncolytic HSV-1 Expressing IL-12 and PD-1 Antibody T3011" @default.
- NCIT_C175473 hasExactSynonym "Oncolytic HSV-1 Expressing IL-12/Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 hasExactSynonym "T 3011" @default.
- NCIT_C175473 hasExactSynonym "T-3011" @default.
- NCIT_C175473 hasExactSynonym "T3011" @default.
- NCIT_C175473 hasExactSynonym "oHSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 inSubset NCIT_C116977 @default.
- NCIT_C175473 inSubset NCIT_C116978 @default.
- NCIT_C175473 inSubset NCIT_C128784 @default.
- NCIT_C175473 inSubset NCIT_C157711 @default.
- NCIT_C175473 inSubset NCIT_C157712 @default.
- NCIT_C175473 inSubset NCIT_C176424 @default.
- NCIT_C175473 inSubset NCIT_C177537 @default.
- NCIT_C175473 type Class @default.
- NCIT_C175473 isDefinedBy ncit.owl @default.
- NCIT_C175473 label "Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011" @default.
- NCIT_C175473 subClassOf NCIT_C129821 @default.
- NCIT_C175473 subClassOf NCIT_C175473 @default.
- NCIT_C175473 subClassOf NCIT_C1908 @default.
- NCIT_C175473 subClassOf NCIT_C1909 @default.
- NCIT_C175473 subClassOf NCIT_C1962 @default.
- NCIT_C175473 subClassOf NCIT_C274 @default.
- NCIT_C175473 subClassOf NCIT_C307 @default.
- NCIT_C175473 subClassOf NCIT_C717 @default.