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- NCIT_C175489 IAO_0000115 "An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, sonrotoclax specifically binds to and inhibits the activity of the pro-survival protein Bcl-2. This restores apoptotic processes and inhibits cell proliferation in Bcl-2-overexpressing tumor cells. Bcl-2, a protein that belongs to the Bcl-2 family, is overexpressed in various tumor cell types and plays an important role in the negative regulation of apoptosis. Its tumor expression is associated with increased drug resistance and cancer cell survival." @default.
- NCIT_C175489 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175489 NCIT_A7 NCIT_C153109 @default.
- NCIT_C175489 NCIT_NHC0 "C175489" @default.
- NCIT_C175489 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175489 NCIT_P107 "Sonrotoclax" @default.
- NCIT_C175489 NCIT_P108 "Sonrotoclax" @default.
- NCIT_C175489 NCIT_P208 "CL1412833" @default.
- NCIT_C175489 NCIT_P210 "2383086-06-2" @default.
- NCIT_C175489 NCIT_P319 "30R67U9KYS" @default.
- NCIT_C175489 NCIT_P322 "CTRP" @default.
- NCIT_C175489 NCIT_P322 "FDA" @default.
- NCIT_C175489 NCIT_P322 "GDC" @default.
- NCIT_C175489 NCIT_P329 "803186" @default.
- NCIT_C175489 NCIT_P330 "803186" @default.
- NCIT_C175489 NCIT_P375 "Bcl-2 Inhibitor BGB-11417" @default.
- NCIT_C175489 NCIT_P399 "803186" @default.
- NCIT_C175489 normalizedInformationContent "100" @default.
- NCIT_C175489 referenceCount "1" @default.
- NCIT_C175489 hasExactSynonym "B-cell Lymphoma-2 Inhibitor BGB-11417" @default.
- NCIT_C175489 hasExactSynonym "BGB 11417" @default.
- NCIT_C175489 hasExactSynonym "BGB-11417" @default.
- NCIT_C175489 hasExactSynonym "BGB11417" @default.
- NCIT_C175489 hasExactSynonym "Bcl-2 Inhibitor BGB-11417" @default.
- NCIT_C175489 hasExactSynonym "SONROTOCLAX" @default.
- NCIT_C175489 hasExactSynonym "Sonrotoclax" @default.
- NCIT_C175489 inSubset NCIT_C116977 @default.
- NCIT_C175489 inSubset NCIT_C116978 @default.
- NCIT_C175489 inSubset NCIT_C128784 @default.
- NCIT_C175489 inSubset NCIT_C157711 @default.
- NCIT_C175489 inSubset NCIT_C157712 @default.
- NCIT_C175489 inSubset NCIT_C176424 @default.
- NCIT_C175489 inSubset NCIT_C177537 @default.
- NCIT_C175489 inSubset NCIT_C63923 @default.
- NCIT_C175489 type Class @default.
- NCIT_C175489 isDefinedBy ncit.owl @default.
- NCIT_C175489 label "Sonrotoclax" @default.
- NCIT_C175489 subClassOf NCIT_C129839 @default.
- NCIT_C175489 subClassOf NCIT_C159200 @default.
- NCIT_C175489 subClassOf NCIT_C163758 @default.
- NCIT_C175489 subClassOf NCIT_C175489 @default.
- NCIT_C175489 subClassOf NCIT_C1908 @default.
- NCIT_C175489 subClassOf NCIT_C1909 @default.
- NCIT_C175489 subClassOf NCIT_C192025 @default.
- NCIT_C175489 subClassOf NCIT_C274 @default.