Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C175490> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C175490 IAO_0000115 "A bispecific antibody-like fusion protein consisting of a trimeric ligand for the T-cell co-stimulatory immune receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) and an antigen-binding fragment (Fab) moiety targeting the tumor-associated protein fibroblast activation protein (FAP), with potential immunomodulating and antineoplastic activities. Upon administration, the FAP/4-1BB-targeting fusion protein RO7122290 targets and binds to both FAP, localized on tumor stromal cells, and 4-1BB, expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. The simultaneous binding of FAP and 4-1BB results in local clustering of FAP-expressing tumor stromal cells and 4-1BB-expressing T-cells, and local immune cell activation through the promotion of T-cell activation, cytokine release and T-cell-mediated anti-tumor immune responses. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. FAP is abundantly expressed by cancer-associated fibroblasts in the majority of solid tumors." @default.
- NCIT_C175490 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175490 NCIT_A7 NCIT_C105113 @default.
- NCIT_C175490 NCIT_A7 NCIT_C17799 @default.
- NCIT_C175490 NCIT_NHC0 "C175490" @default.
- NCIT_C175490 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175490 NCIT_P107 "FAP/4-1BB-targeting Fusion Protein RO7122290" @default.
- NCIT_C175490 NCIT_P108 "FAP/4-1BB-targeting Fusion Protein RO7122290" @default.
- NCIT_C175490 NCIT_P208 "CL1412832" @default.
- NCIT_C175490 NCIT_P322 "CTRP" @default.
- NCIT_C175490 NCIT_P322 "GDC" @default.
- NCIT_C175490 NCIT_P329 "803283" @default.
- NCIT_C175490 NCIT_P330 "803283" @default.
- NCIT_C175490 NCIT_P375 "FAP/4-1BB-targeting Fusion Protein RO7122290" @default.
- NCIT_C175490 NCIT_P399 "803283" @default.
- NCIT_C175490 normalizedInformationContent "100" @default.
- NCIT_C175490 referenceCount "1" @default.
- NCIT_C175490 hasExactSynonym "FAP/4-1BB-targeting Fusion Protein RO7122290" @default.
- NCIT_C175490 hasExactSynonym "RO 7122290" @default.
- NCIT_C175490 hasExactSynonym "RO-7122290" @default.
- NCIT_C175490 hasExactSynonym "RO7122290" @default.
- NCIT_C175490 inSubset NCIT_C116977 @default.
- NCIT_C175490 inSubset NCIT_C116978 @default.
- NCIT_C175490 inSubset NCIT_C128784 @default.
- NCIT_C175490 inSubset NCIT_C157711 @default.
- NCIT_C175490 inSubset NCIT_C157712 @default.
- NCIT_C175490 inSubset NCIT_C176424 @default.
- NCIT_C175490 inSubset NCIT_C177537 @default.
- NCIT_C175490 type Class @default.
- NCIT_C175490 isDefinedBy ncit.owl @default.
- NCIT_C175490 label "FAP/4-1BB-targeting Fusion Protein RO7122290" @default.
- NCIT_C175490 subClassOf NCIT_C129820 @default.
- NCIT_C175490 subClassOf NCIT_C175490 @default.
- NCIT_C175490 subClassOf NCIT_C1908 @default.
- NCIT_C175490 subClassOf NCIT_C1909 @default.
- NCIT_C175490 subClassOf NCIT_C274 @default.
- NCIT_C175490 subClassOf NCIT_C308 @default.