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- NCIT_C175536 IAO_0000115 "A therapeutic DNA vaccine encoding human calreticulin (CRT) linked to human papillomavirus (HPV) type 16 E6, E7, and L2 proteins, with potential immunomodulating and antineoplastic activities. Upon administration via intramuscular injection with electroporation, the pNGVL4a-CRT-E6E7L2 DNA vaccine expresses HPV16 E6, E7 and L2 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response and humoral immune responses against tumor cells expressing these proteins, resulting in tumor cell lysis and tumor cell death. In addition, HPV16 L2-specific neutralizing antibody may prevent a broad spectrum of HPV infections and HPV-associated cancers. The heat shock protein CRT may potentiate MHC class I presentation to antigen-specific CD8-positive T-cells, enhancing the induction of cellular immunity and the potency of the vaccine." @default.
- NCIT_C175536 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175536 NCIT_A7 NCIT_C1179 @default.
- NCIT_C175536 NCIT_A7 NCIT_C1397 @default.
- NCIT_C175536 NCIT_A7 NCIT_C181990 @default.
- NCIT_C175536 NCIT_NHC0 "C175536" @default.
- NCIT_C175536 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175536 NCIT_P107 "pNGVL4a-CRT-E6E7L2 DNA Vaccine" @default.
- NCIT_C175536 NCIT_P108 "pNGVL4a-CRT-E6E7L2 DNA Vaccine" @default.
- NCIT_C175536 NCIT_P208 "CL1412894" @default.
- NCIT_C175536 NCIT_P322 "CTRP" @default.
- NCIT_C175536 NCIT_P322 "GDC" @default.
- NCIT_C175536 NCIT_P329 "803294" @default.
- NCIT_C175536 NCIT_P330 "803294" @default.
- NCIT_C175536 NCIT_P375 "pNGVL4a-CRT-E6E7L2 DNA Vaccine" @default.
- NCIT_C175536 NCIT_P399 "803294" @default.
- NCIT_C175536 normalizedInformationContent "100" @default.
- NCIT_C175536 referenceCount "1" @default.
- NCIT_C175536 hasExactSynonym "pNGVL4a-CRT-E6E7L2 DNA Vaccine" @default.
- NCIT_C175536 hasExactSynonym "pNGVL4a-CRT-E6E7L2" @default.
- NCIT_C175536 hasExactSynonym "pNGVL4a-CRTE6E7L2" @default.
- NCIT_C175536 hasExactSynonym "pNGVL4aCRTE6E7L2 DNA Vaccine" @default.
- NCIT_C175536 hasExactSynonym "pNGVL4aCRTE6E7L2" @default.
- NCIT_C175536 inSubset NCIT_C116977 @default.
- NCIT_C175536 inSubset NCIT_C116978 @default.
- NCIT_C175536 inSubset NCIT_C128784 @default.
- NCIT_C175536 inSubset NCIT_C157711 @default.
- NCIT_C175536 inSubset NCIT_C157712 @default.
- NCIT_C175536 inSubset NCIT_C176424 @default.
- NCIT_C175536 inSubset NCIT_C177537 @default.
- NCIT_C175536 type Class @default.
- NCIT_C175536 isDefinedBy ncit.owl @default.
- NCIT_C175536 label "pNGVL4a-CRT-E6E7L2 DNA Vaccine" @default.
- NCIT_C175536 subClassOf NCIT_C129820 @default.
- NCIT_C175536 subClassOf NCIT_C1663 @default.
- NCIT_C175536 subClassOf NCIT_C175536 @default.
- NCIT_C175536 subClassOf NCIT_C1908 @default.
- NCIT_C175536 subClassOf NCIT_C1909 @default.
- NCIT_C175536 subClassOf NCIT_C274 @default.
- NCIT_C175536 subClassOf NCIT_C307 @default.
- NCIT_C175536 subClassOf NCIT_C308 @default.
- NCIT_C175536 subClassOf NCIT_C39619 @default.
- NCIT_C175536 subClassOf NCIT_C923 @default.