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- NCIT_C175543 IAO_0000115 "An inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, Axl/Mer inhibitor PF-07265807 specifically targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with drug resistance and poor prognosis." @default.
- NCIT_C175543 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175543 NCIT_A7 NCIT_C17475 @default.
- NCIT_C175543 NCIT_A7 NCIT_C26383 @default.
- NCIT_C175543 NCIT_NHC0 "C175543" @default.
- NCIT_C175543 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175543 NCIT_P107 "Axl/Mer Inhibitor PF-07265807" @default.
- NCIT_C175543 NCIT_P108 "Axl/Mer Inhibitor PF-07265807" @default.
- NCIT_C175543 NCIT_P208 "CL1412891" @default.
- NCIT_C175543 NCIT_P322 "CTRP" @default.
- NCIT_C175543 NCIT_P322 "GDC" @default.
- NCIT_C175543 NCIT_P329 "803296" @default.
- NCIT_C175543 NCIT_P330 "803296" @default.
- NCIT_C175543 NCIT_P366 "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C175543 NCIT_P375 "Axl/Mer Inhibitor PF-07265807" @default.
- NCIT_C175543 NCIT_P399 "803296" @default.
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- NCIT_C175543 normalizedInformationContent "100" @default.
- NCIT_C175543 referenceCount "1" @default.
- NCIT_C175543 hasExactSynonym "Axl/Mer Inhibitor PF-07265807" @default.
- NCIT_C175543 hasExactSynonym "PF 07265807" @default.
- NCIT_C175543 hasExactSynonym "PF-07265807" @default.
- NCIT_C175543 hasExactSynonym "PF07265807" @default.
- NCIT_C175543 inSubset NCIT_C116977 @default.
- NCIT_C175543 inSubset NCIT_C116978 @default.
- NCIT_C175543 inSubset NCIT_C128784 @default.
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- NCIT_C175543 inSubset NCIT_C176424 @default.
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- NCIT_C175543 type Class @default.
- NCIT_C175543 isDefinedBy ncit.owl @default.
- NCIT_C175543 label "Axl/Mer Inhibitor PF-07265807" @default.
- NCIT_C175543 subClassOf B2b886a34272a7eb99be0b5e9652c0d29 @default.
- NCIT_C175543 subClassOf B2d6a5aa5de460f1097250e5933127192 @default.
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- NCIT_C175543 subClassOf Bfeaa67448400cd0b20cdedc53e4bb7d6 @default.
- NCIT_C175543 subClassOf NCIT_C129824 @default.
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- NCIT_C175543 subClassOf NCIT_C1404 @default.
- NCIT_C175543 subClassOf NCIT_C175543 @default.
- NCIT_C175543 subClassOf NCIT_C1908 @default.
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- NCIT_C175543 subClassOf NCIT_C1967 @default.
- NCIT_C175543 subClassOf NCIT_C200418 @default.
- NCIT_C175543 subClassOf NCIT_C2189 @default.
- NCIT_C175543 subClassOf NCIT_C274 @default.
- NCIT_C175543 subClassOf NCIT_C471 @default.