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- NCIT_C175557 IAO_0000115 "An orally bioavailable inhibitor of the serine/threonine kinases AKT (protein kinase B), 90S ribosome S6 kinase (p90RSK; RSK) and 70S ribosome S6 kinase (p70S6K; S6K), with potential antineoplastic activity. Upon oral administration, AKT/RSK/S6K inhibitor TAS0612 targets, binds to, and inhibits the activity of AKT, p90RSK and p70S6K. This inhibits both the AKT/mTOR/p70S6K and RAS/RAF/MEK/p90RSK signaling pathways and prevents the phosphorylation, nuclear translocation, and activation of the transcription factor Y-box-binding protein 1 (YBX1; YB-1). This may lead to cell cycle arrest, an induction of apoptosis, and an inhibition of tumor cell proliferation in tumor cells that have overactivated AKT/mTOR/p70S6K and RAS/RAF/MEK/p90RSK signaling pathways. Nuclear expression of YBX1 is associated with drug resistance such as antiestrogen resistance. AKT, RSK and S6K play key roles in tumor cell proliferation, differentiation, survival, and metastasis." @default.
- NCIT_C175557 NCIT_A7 NCIT_C104766 @default.
- NCIT_C175557 NCIT_A7 NCIT_C41625 @default.
- NCIT_C175557 NCIT_A7 NCIT_C84317 @default.
- NCIT_C175557 NCIT_NHC0 "C175557" @default.
- NCIT_C175557 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175557 NCIT_P107 "AKT/RSK/S6K Inhibitor TAS0612" @default.
- NCIT_C175557 NCIT_P108 "AKT/RSK/S6K Inhibitor TAS0612" @default.
- NCIT_C175557 NCIT_P208 "CL1413020" @default.
- NCIT_C175557 NCIT_P322 "CTRP" @default.
- NCIT_C175557 NCIT_P322 "GDC" @default.
- NCIT_C175557 normalizedInformationContent "100" @default.
- NCIT_C175557 referenceCount "1" @default.
- NCIT_C175557 hasExactSynonym "AKT/RSK/S6K Inhibitor TAS0612" @default.
- NCIT_C175557 hasExactSynonym "AKT/p90RSK/p70S6K Inhibitor TAS0612" @default.
- NCIT_C175557 hasExactSynonym "TAS 0612" @default.
- NCIT_C175557 hasExactSynonym "TAS-0612" @default.
- NCIT_C175557 hasExactSynonym "TAS0612" @default.
- NCIT_C175557 inSubset NCIT_C116977 @default.
- NCIT_C175557 inSubset NCIT_C116978 @default.
- NCIT_C175557 inSubset NCIT_C128784 @default.
- NCIT_C175557 inSubset NCIT_C157711 @default.
- NCIT_C175557 inSubset NCIT_C157712 @default.
- NCIT_C175557 type Class @default.
- NCIT_C175557 isDefinedBy ncit.owl @default.
- NCIT_C175557 label "AKT/RSK/S6K Inhibitor TAS0612" @default.
- NCIT_C175557 subClassOf NCIT_C129824 @default.
- NCIT_C175557 subClassOf NCIT_C129825 @default.
- NCIT_C175557 subClassOf NCIT_C1404 @default.
- NCIT_C175557 subClassOf NCIT_C155764 @default.
- NCIT_C175557 subClassOf NCIT_C1742 @default.
- NCIT_C175557 subClassOf NCIT_C175557 @default.
- NCIT_C175557 subClassOf NCIT_C1908 @default.
- NCIT_C175557 subClassOf NCIT_C1909 @default.
- NCIT_C175557 subClassOf NCIT_C2189 @default.
- NCIT_C175557 subClassOf NCIT_C274 @default.
- NCIT_C175557 subClassOf NCIT_C471 @default.
- NCIT_C175557 subClassOf NCIT_C61074 @default.