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- NCIT_C175579 IAO_0000115 "A preparation of adapter molecules consisting of an antibody fragment (Fab) targeting CD19 linked to a 14 aa peptide epitope, or peptide neo-epitope (PNE), recognizable by CLBR001, that may be used to activate CLBR001. Upon administration of CD19-specific adapter molecule SWI019, and upon co-administration of CLBR001, the Fab moiety of SWI019 targets and binds to tumor cells expressing CD19, and the PNE of SWI019 binds to the binding domain of CLBR001, thereby activating CLBR001. This induces selective toxicity in and causes lysis of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
- NCIT_C175579 NCIT_A7 NCIT_C38894 @default.
- NCIT_C175579 NCIT_NHC0 "C175579" @default.
- NCIT_C175579 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175579 NCIT_P107 "CD19-specific Adapter Molecule SWI019" @default.
- NCIT_C175579 NCIT_P108 "CD19-specific Adapter Molecule SWI019" @default.
- NCIT_C175579 NCIT_P208 "CL1413000" @default.
- NCIT_C175579 NCIT_P322 "CTRP" @default.
- NCIT_C175579 NCIT_P322 "GDC" @default.
- NCIT_C175579 normalizedInformationContent "100" @default.
- NCIT_C175579 referenceCount "1" @default.
- NCIT_C175579 hasExactSynonym "Alpha-CD19 Fab-based Switch SWI019" @default.
- NCIT_C175579 hasExactSynonym "Anti-CD19 Antibody SWI019" @default.
- NCIT_C175579 hasExactSynonym "CD19-specific Adapter Molecule SWI019" @default.
- NCIT_C175579 hasExactSynonym "SWI 019" @default.
- NCIT_C175579 hasExactSynonym "SWI-019" @default.
- NCIT_C175579 hasExactSynonym "SWI019" @default.
- NCIT_C175579 inSubset NCIT_C116977 @default.
- NCIT_C175579 inSubset NCIT_C116978 @default.
- NCIT_C175579 inSubset NCIT_C128784 @default.
- NCIT_C175579 inSubset NCIT_C157711 @default.
- NCIT_C175579 inSubset NCIT_C157712 @default.
- NCIT_C175579 type Class @default.
- NCIT_C175579 isDefinedBy ncit.owl @default.
- NCIT_C175579 label "CD19-specific Adapter Molecule SWI019" @default.
- NCIT_C175579 subClassOf NCIT_C1512 @default.
- NCIT_C175579 subClassOf NCIT_C175579 @default.
- NCIT_C175579 subClassOf NCIT_C1908 @default.
- NCIT_C175579 subClassOf NCIT_C1909 @default.
- NCIT_C175579 subClassOf NCIT_C307 @default.
- NCIT_C175579 subClassOf NCIT_C308 @default.