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- NCIT_C175603 IAO_0000115 "A humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface antigen CD47, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD47 monoclonal antibody ZL-1201 targets and binds to CD47 expressed on tumor cells, blocking the interaction of CD47 with signal regulatory protein alpha (SIRPa) expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of macrophage activation and phagocytosis of cancer cells. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), which is expressed on macrophages, and results in macrophage activation and the specific phagocytosis of tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate." @default.
- NCIT_C175603 NCIT_A7 NCIT_C25795 @default.
- NCIT_C175603 NCIT_NHC0 "C175603" @default.
- NCIT_C175603 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175603 NCIT_P107 "Anti-CD47 Monoclonal Antibody ZL-1201" @default.
- NCIT_C175603 NCIT_P108 "Anti-CD47 Monoclonal Antibody ZL-1201" @default.
- NCIT_C175603 NCIT_P208 "CL1412925" @default.
- NCIT_C175603 NCIT_P322 "CTRP" @default.
- NCIT_C175603 NCIT_P322 "GDC" @default.
- NCIT_C175603 NCIT_P329 "803163" @default.
- NCIT_C175603 NCIT_P330 "803163" @default.
- NCIT_C175603 NCIT_P399 "803163" @default.
- NCIT_C175603 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C175603 NCIT_R124 NCIT_C18219 @default.
- NCIT_C175603 NCIT_R124 NCIT_C19986 @default.
- NCIT_C175603 NCIT_R124 NCIT_C40474 @default.
- NCIT_C175603 normalizedInformationContent "100" @default.
- NCIT_C175603 referenceCount "1" @default.
- NCIT_C175603 hasExactSynonym "Anti-CD47 Monoclonal Antibody ZL-1201" @default.
- NCIT_C175603 hasExactSynonym "ZL 1201" @default.
- NCIT_C175603 hasExactSynonym "ZL-1201" @default.
- NCIT_C175603 hasExactSynonym "ZL1201" @default.
- NCIT_C175603 inSubset NCIT_C116977 @default.
- NCIT_C175603 inSubset NCIT_C116978 @default.
- NCIT_C175603 inSubset NCIT_C128784 @default.
- NCIT_C175603 inSubset NCIT_C157711 @default.
- NCIT_C175603 inSubset NCIT_C157712 @default.
- NCIT_C175603 inSubset NCIT_C176424 @default.
- NCIT_C175603 type Class @default.
- NCIT_C175603 isDefinedBy ncit.owl @default.
- NCIT_C175603 label "Anti-CD47 Monoclonal Antibody ZL-1201" @default.
- NCIT_C175603 subClassOf Bcff6b084af48768eab2cb9616bc8f301 @default.
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- NCIT_C175603 subClassOf NCIT_C129821 @default.
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- NCIT_C175603 subClassOf NCIT_C159583 @default.
- NCIT_C175603 subClassOf NCIT_C163758 @default.
- NCIT_C175603 subClassOf NCIT_C175603 @default.
- NCIT_C175603 subClassOf NCIT_C1908 @default.
- NCIT_C175603 subClassOf NCIT_C1909 @default.
- NCIT_C175603 subClassOf NCIT_C192655 @default.
- NCIT_C175603 subClassOf NCIT_C20401 @default.
- NCIT_C175603 subClassOf NCIT_C274 @default.
- NCIT_C175603 subClassOf NCIT_C307 @default.
- NCIT_C175603 subClassOf NCIT_C308 @default.