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- NCIT_C175786 IAO_0000115 "A phosphoryloxymethyl (POM) ester-based prodrug of ciclopirox (CPX), a synthetic, broad-spectrum antifungal agent with antibacterial, anti-inflammatory and potential antineoplastic activities. Upon intravenous administration of fosciclopirox, the POM moiety is cleaved off by phosphatases and the active metabolite CPX is released. Although its exact anticancer mechanism is not yet fully elucidated, CPX has been shown to inhibit tumor cell proliferation, induce apoptosis, and reduce tumor cell mobility in certain cancer types. CPX inhibits Notch1 activation and inhibits the Notch1-mediated signaling pathway, which is upregulated in many cancer cell types. This inhibits Notch downstream target proteins, inhibits the expression of gamma-secretase complex proteins, and prevents proliferation in susceptible cancer cells. CPX inhibits the iron-containing enzymes, catalase and peroxidase, which facilitate the decomposition of hydrogen peroxide, a reactive oxygen species (ROS) involved in oxidative stress. CPX also inhibits the iron-dependent enzyme ribonucleotide reductase, which is essential in DNA synthesis. CPX downregulates protein expression of cyclin D1 and cyclin E1, as well as their enzymatic counterparts cyclin-dependent kinases 4 and 2 (CDK4 and CDK2), which may inhibit tumor cell proliferation by slowing cell cycle progression from G1/G0 to S phase. Further, CPX may induce apoptosis by downregulating the expression of anti-apoptotic proteins, Bcl-xL and survivin, and increasing cleavage of Bcl-2. Additionally, CPX may inhibit tumor cell proliferation, survival and motility by inhibiting the phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mTORC1). The CPX-POM prodrug improves the solubility of CPX and increases systemic efficacy." @default.
- NCIT_C175786 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175786 NCIT_NHC0 "C175786" @default.
- NCIT_C175786 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175786 NCIT_P107 "Fosciclopirox" @default.
- NCIT_C175786 NCIT_P108 "Fosciclopirox" @default.
- NCIT_C175786 NCIT_P208 "CL562696" @default.
- NCIT_C175786 NCIT_P210 "1380539-06-9" @default.
- NCIT_C175786 NCIT_P319 "G8FR269QPQ" @default.
- NCIT_C175786 NCIT_P322 "CTRP" @default.
- NCIT_C175786 NCIT_P322 "FDA" @default.
- NCIT_C175786 NCIT_P322 "GDC" @default.
- NCIT_C175786 NCIT_P329 "794795" @default.
- NCIT_C175786 NCIT_P330 "794795" @default.
- NCIT_C175786 NCIT_P375 "Ciclopirox Prodrug CPX-POM" @default.
- NCIT_C175786 NCIT_P399 "794795" @default.
- NCIT_C175786 normalizedInformationContent "100" @default.
- NCIT_C175786 referenceCount "1" @default.
- NCIT_C175786 hasExactSynonym "CPX POM" @default.
- NCIT_C175786 hasExactSynonym "CPX-POM" @default.
- NCIT_C175786 hasExactSynonym "CPXPOM" @default.
- NCIT_C175786 hasExactSynonym "Ciclopirox Prodrug CPX-POM" @default.
- NCIT_C175786 hasExactSynonym "Ciclopirox Prodrug" @default.
- NCIT_C175786 hasExactSynonym "Ciclopirox-POM" @default.
- NCIT_C175786 hasExactSynonym "FOSCICLOPIROX" @default.
- NCIT_C175786 hasExactSynonym "Fosciclopirox" @default.
- NCIT_C175786 inSubset NCIT_C116977 @default.
- NCIT_C175786 inSubset NCIT_C116978 @default.
- NCIT_C175786 inSubset NCIT_C128784 @default.
- NCIT_C175786 inSubset NCIT_C157711 @default.
- NCIT_C175786 inSubset NCIT_C157712 @default.
- NCIT_C175786 inSubset NCIT_C176424 @default.
- NCIT_C175786 inSubset NCIT_C177537 @default.
- NCIT_C175786 inSubset NCIT_C63923 @default.
- NCIT_C175786 type Class @default.
- NCIT_C175786 isDefinedBy ncit.owl @default.
- NCIT_C175786 label "Fosciclopirox" @default.
- NCIT_C175786 subClassOf NCIT_C175786 @default.
- NCIT_C175786 subClassOf NCIT_C1908 @default.
- NCIT_C175786 subClassOf NCIT_C1909 @default.
- NCIT_C175786 subClassOf NCIT_C2189 @default.
- NCIT_C175786 subClassOf NCIT_C254 @default.
- NCIT_C175786 subClassOf NCIT_C274 @default.
- NCIT_C175786 subClassOf NCIT_C514 @default.