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- NCIT_C175823 IAO_0000115 "An antibody-drug conjugate (ADC), consisting of mipasetamab, a humanized immunoglobulin (Ig) G1 monoclonal antibody directed against AXL receptor tyrosine kinase (AXL; UFO) that is site-specifically conjugated to uzoptitine (PL1601), which contains a valine-alanine cleavable linker and SG3199, a cytotoxic pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon administration of mipasetamab uzoptirine, mipasetamab binds to AXL, which is expressed on the surfaces of a variety of cancer cell types. Upon endocytosis and enzymatic cleavage, SG3199 is released and forms highly cytotoxic DNA interstrand cross-links, thereby blocking cell division and killing AXL-expressing cancer cells. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases, is overexpressed by many tumor cell types, and plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis." @default.
- NCIT_C175823 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175823 NCIT_NHC0 "C175823" @default.
- NCIT_C175823 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175823 NCIT_P107 "Mipasetamab Uzoptirine" @default.
- NCIT_C175823 NCIT_P108 "Mipasetamab Uzoptirine" @default.
- NCIT_C175823 NCIT_P208 "CL969909" @default.
- NCIT_C175823 NCIT_P210 "2304799-73-1" @default.
- NCIT_C175823 NCIT_P319 "71KV7F609O" @default.
- NCIT_C175823 NCIT_P322 "CTRP" @default.
- NCIT_C175823 NCIT_P322 "FDA" @default.
- NCIT_C175823 NCIT_P322 "GDC" @default.
- NCIT_C175823 NCIT_P375 "Anti-AXL/PBD Antibody-drug Conjugate ADCT-601" @default.
- NCIT_C175823 NCIT_P399 "798273" @default.
- NCIT_C175823 normalizedInformationContent "100" @default.
- NCIT_C175823 referenceCount "1" @default.
- NCIT_C175823 hasExactSynonym "ADC ADCT-601" @default.
- NCIT_C175823 hasExactSynonym "ADCT 601" @default.
- NCIT_C175823 hasExactSynonym "ADCT-601" @default.
- NCIT_C175823 hasExactSynonym "ADCT601" @default.
- NCIT_C175823 hasExactSynonym "Anti-AXL/PBD ADC ADCT-601" @default.
- NCIT_C175823 hasExactSynonym "Anti-AXL/PBD Antibody-drug Conjugate ADCT-601" @default.
- NCIT_C175823 hasExactSynonym "BGB 601" @default.
- NCIT_C175823 hasExactSynonym "BGB-601" @default.
- NCIT_C175823 hasExactSynonym "MIPASETAMAB UZOPTIRINE" @default.
- NCIT_C175823 hasExactSynonym "Mipasetamab Uzoptirine" @default.
- NCIT_C175823 inSubset NCIT_C116977 @default.
- NCIT_C175823 inSubset NCIT_C116978 @default.
- NCIT_C175823 inSubset NCIT_C128784 @default.
- NCIT_C175823 inSubset NCIT_C157711 @default.
- NCIT_C175823 inSubset NCIT_C157712 @default.
- NCIT_C175823 inSubset NCIT_C176424 @default.
- NCIT_C175823 inSubset NCIT_C177537 @default.
- NCIT_C175823 inSubset NCIT_C63923 @default.
- NCIT_C175823 type Class @default.
- NCIT_C175823 isDefinedBy ncit.owl @default.
- NCIT_C175823 label "Mipasetamab Uzoptirine" @default.
- NCIT_C175823 subClassOf NCIT_C129821 @default.
- NCIT_C175823 subClassOf NCIT_C129823 @default.
- NCIT_C175823 subClassOf NCIT_C1512 @default.
- NCIT_C175823 subClassOf NCIT_C175823 @default.
- NCIT_C175823 subClassOf NCIT_C1908 @default.
- NCIT_C175823 subClassOf NCIT_C1909 @default.
- NCIT_C175823 subClassOf NCIT_C201141 @default.
- NCIT_C175823 subClassOf NCIT_C274 @default.
- NCIT_C175823 subClassOf NCIT_C307 @default.
- NCIT_C175823 subClassOf NCIT_C308 @default.