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- NCIT_C175875 IAO_0000115 "A virus-like particle (VLP) composed of the Qbeta bacteriophage capsid encapsulating the toll-like receptor 9 (TLR9) agonist G10, an unmethylated CpG-A oligodeoxynucleotide (ODN), with potential immunostimulating and antineoplastic activities. Upon administration of vidutolimod, the VLPs are specifically taken up by and release the oligonucleotide into antigen-presenting cells (APCs), including dendritic cells (DCs). In turn, the oligonucleotide binds to and activates intracellular TLR9. This stimulates immune signaling pathways, induces the innate immune system and may promote the immune system to attack tumor cells. VLPs stimulate the immune system. TLR9, a member of the TLR family, plays a key role in both pathogen recognition and the activation of innate immunity." @default.
- NCIT_C175875 NCIT_A32 NCIT_C1909 @default.
- NCIT_C175875 NCIT_A7 NCIT_C96048 @default.
- NCIT_C175875 NCIT_NHC0 "C175875" @default.
- NCIT_C175875 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175875 NCIT_P107 "Vidutolimod" @default.
- NCIT_C175875 NCIT_P108 "Vidutolimod" @default.
- NCIT_C175875 NCIT_P208 "CL1413087" @default.
- NCIT_C175875 NCIT_P210 "147063-80-7" @default.
- NCIT_C175875 NCIT_P319 "D68OW5RS98" @default.
- NCIT_C175875 NCIT_P322 "CTRP" @default.
- NCIT_C175875 NCIT_P322 "FDA" @default.
- NCIT_C175875 NCIT_P322 "GDC" @default.
- NCIT_C175875 NCIT_P375 "VLP-encapsulated TLR9 Agonist CMP-001" @default.
- NCIT_C175875 NCIT_P399 "779977" @default.
- NCIT_C175875 normalizedInformationContent "100" @default.
- NCIT_C175875 referenceCount "1" @default.
- NCIT_C175875 hasExactSynonym "ARB-1598" @default.
- NCIT_C175875 hasExactSynonym "CMP-001" @default.
- NCIT_C175875 hasExactSynonym "CYT 003" @default.
- NCIT_C175875 hasExactSynonym "CYT-003" @default.
- NCIT_C175875 hasExactSynonym "QbG10" @default.
- NCIT_C175875 hasExactSynonym "VIDUTOLIMOD" @default.
- NCIT_C175875 hasExactSynonym "VLP-encapsulated TLR9 Agonist CMP-001" @default.
- NCIT_C175875 hasExactSynonym "Vidutolimod" @default.
- NCIT_C175875 inSubset NCIT_C116977 @default.
- NCIT_C175875 inSubset NCIT_C116978 @default.
- NCIT_C175875 inSubset NCIT_C128784 @default.
- NCIT_C175875 inSubset NCIT_C157711 @default.
- NCIT_C175875 inSubset NCIT_C157712 @default.
- NCIT_C175875 inSubset NCIT_C176424 @default.
- NCIT_C175875 inSubset NCIT_C177537 @default.
- NCIT_C175875 inSubset NCIT_C63923 @default.
- NCIT_C175875 type Class @default.
- NCIT_C175875 isDefinedBy ncit.owl @default.
- NCIT_C175875 label "Vidutolimod" @default.
- NCIT_C175875 subClassOf NCIT_C175875 @default.
- NCIT_C175875 subClassOf NCIT_C177174 @default.
- NCIT_C175875 subClassOf NCIT_C177175 @default.
- NCIT_C175875 subClassOf NCIT_C1908 @default.
- NCIT_C175875 subClassOf NCIT_C1909 @default.
- NCIT_C175875 subClassOf NCIT_C2139 @default.
- NCIT_C175875 subClassOf NCIT_C308 @default.