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- NCIT_C175940 IAO_0000115 "An orally bioavailable, amorphous solid dispersion formulation of the steroidal compound abiraterone, with potential antiandrogen activity. Upon oral administration, abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. This may suppress testosterone production by both the testes and the adrenals to castrate-range levels." @default.
- NCIT_C175940 NCIT_NHC0 "C175940" @default.
- NCIT_C175940 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175940 NCIT_P108 "Abiraterone Amorphous Solid Dispersion Formulation DST-2970" @default.
- NCIT_C175940 NCIT_P208 "CL1413145" @default.
- NCIT_C175940 NCIT_P322 "GDC" @default.
- NCIT_C175940 NCIT_P329 "803232" @default.
- NCIT_C175940 NCIT_P330 "803232" @default.
- NCIT_C175940 NCIT_P399 "803232" @default.
- NCIT_C175940 normalizedInformationContent "100" @default.
- NCIT_C175940 referenceCount "1" @default.
- NCIT_C175940 hasExactSynonym "Abiraterone Amorphous Solid Dispersion Formulation DST-2970" @default.
- NCIT_C175940 hasExactSynonym "Abiraterone KinetiSol Formulation DST-2970" @default.
- NCIT_C175940 hasExactSynonym "DST 2970" @default.
- NCIT_C175940 hasExactSynonym "DST-2970" @default.
- NCIT_C175940 hasExactSynonym "DST2970" @default.
- NCIT_C175940 inSubset NCIT_C128784 @default.
- NCIT_C175940 inSubset NCIT_C157711 @default.
- NCIT_C175940 inSubset NCIT_C157712 @default.
- NCIT_C175940 inSubset NCIT_C176424 @default.
- NCIT_C175940 type Class @default.
- NCIT_C175940 isDefinedBy ncit.owl @default.
- NCIT_C175940 label "Abiraterone Amorphous Solid Dispersion Formulation DST-2970" @default.
- NCIT_C175940 subClassOf NCIT_C147908 @default.
- NCIT_C175940 subClassOf NCIT_C147923 @default.
- NCIT_C175940 subClassOf NCIT_C175940 @default.
- NCIT_C175940 subClassOf NCIT_C1908 @default.
- NCIT_C175940 subClassOf NCIT_C1909 @default.
- NCIT_C175940 subClassOf NCIT_C242 @default.
- NCIT_C175940 subClassOf NCIT_C471 @default.
- NCIT_C175940 subClassOf NCIT_C547 @default.