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- NCIT_C175942 IAO_0000115 "An orally bioavailable inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor MPT0B640 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to the inhibition of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins." @default.
- NCIT_C175942 NCIT_NHC0 "C175942" @default.
- NCIT_C175942 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175942 NCIT_P108 "Hsp90 Inhibitor MPT0B640" @default.
- NCIT_C175942 NCIT_P208 "CL1413143" @default.
- NCIT_C175942 NCIT_P322 "GDC" @default.
- NCIT_C175942 NCIT_P329 "803236" @default.
- NCIT_C175942 NCIT_P330 "803236" @default.
- NCIT_C175942 NCIT_P399 "803236" @default.
- NCIT_C175942 NCIT_R125 NCIT_C17828 @default.
- NCIT_C175942 NCIT_R125 NCIT_C20150 @default.
- NCIT_C175942 NCIT_R125 NCIT_C20480 @default.
- NCIT_C175942 NCIT_R125 NCIT_C40715 @default.
- NCIT_C175942 NCIT_R125 NCIT_C41515 @default.
- NCIT_C175942 NCIT_R125 NCIT_C51037 @default.
- NCIT_C175942 normalizedInformationContent "100" @default.
- NCIT_C175942 referenceCount "1" @default.
- NCIT_C175942 hasExactSynonym "Hsp90 Inhibitor MPT0B640" @default.
- NCIT_C175942 hasExactSynonym "MPT0B 640" @default.
- NCIT_C175942 hasExactSynonym "MPT0B-640" @default.
- NCIT_C175942 hasExactSynonym "MPT0B640" @default.
- NCIT_C175942 inSubset NCIT_C128784 @default.
- NCIT_C175942 inSubset NCIT_C157711 @default.
- NCIT_C175942 inSubset NCIT_C157712 @default.
- NCIT_C175942 inSubset NCIT_C176424 @default.
- NCIT_C175942 type Class @default.
- NCIT_C175942 isDefinedBy ncit.owl @default.
- NCIT_C175942 label "Hsp90 Inhibitor MPT0B640" @default.
- NCIT_C175942 subClassOf NCIT_C129824 @default.
- NCIT_C175942 subClassOf NCIT_C156880 @default.
- NCIT_C175942 subClassOf NCIT_C175942 @default.
- NCIT_C175942 subClassOf NCIT_C1908 @default.
- NCIT_C175942 subClassOf NCIT_C1909 @default.
- NCIT_C175942 subClassOf NCIT_C2189 @default.
- NCIT_C175942 subClassOf NCIT_C274 @default.
- NCIT_C175942 subClassOf NCIT_C74526 @default.