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- NCIT_C175970 IAO_0000115 "A recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA-4 monoclonal antibody IBI310 targets and binds to CTLA-4 expressed on T-cells, and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C175970 NCIT_A7 NCIT_C17489 @default.
- NCIT_C175970 NCIT_NHC0 "C175970" @default.
- NCIT_C175970 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C175970 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C175970 NCIT_P108 "Anti-CTLA-4 Monoclonal Antibody IBI310" @default.
- NCIT_C175970 NCIT_P208 "CL1413421" @default.
- NCIT_C175970 NCIT_P322 "GDC" @default.
- NCIT_C175970 NCIT_P329 "803187" @default.
- NCIT_C175970 NCIT_P330 "803187" @default.
- NCIT_C175970 NCIT_P399 "803187" @default.
- NCIT_C175970 NCIT_R124 NCIT_C17710 @default.
- NCIT_C175970 NCIT_R124 NCIT_C17828 @default.
- NCIT_C175970 NCIT_R124 NCIT_C18219 @default.
- NCIT_C175970 NCIT_R124 NCIT_C19986 @default.
- NCIT_C175970 NCIT_R124 NCIT_C40474 @default.
- NCIT_C175970 normalizedInformationContent "100" @default.
- NCIT_C175970 referenceCount "1" @default.
- NCIT_C175970 hasExactSynonym "Anti-CTLA-4 Monoclonal Antibody IBI310" @default.
- NCIT_C175970 hasExactSynonym "IBI 310" @default.
- NCIT_C175970 hasExactSynonym "IBI-310" @default.
- NCIT_C175970 hasExactSynonym "IBI310" @default.
- NCIT_C175970 inSubset NCIT_C128784 @default.
- NCIT_C175970 inSubset NCIT_C157711 @default.
- NCIT_C175970 inSubset NCIT_C157712 @default.
- NCIT_C175970 inSubset NCIT_C176424 @default.
- NCIT_C175970 type Class @default.
- NCIT_C175970 isDefinedBy ncit.owl @default.
- NCIT_C175970 label "Anti-CTLA-4 Monoclonal Antibody IBI310" @default.
- NCIT_C175970 subClassOf NCIT_C128036 @default.
- NCIT_C175970 subClassOf NCIT_C129821 @default.
- NCIT_C175970 subClassOf NCIT_C129822 @default.
- NCIT_C175970 subClassOf NCIT_C141144 @default.
- NCIT_C175970 subClassOf NCIT_C143250 @default.
- NCIT_C175970 subClassOf NCIT_C163758 @default.
- NCIT_C175970 subClassOf NCIT_C175970 @default.
- NCIT_C175970 subClassOf NCIT_C1908 @default.
- NCIT_C175970 subClassOf NCIT_C1909 @default.
- NCIT_C175970 subClassOf NCIT_C191738 @default.
- NCIT_C175970 subClassOf NCIT_C20401 @default.
- NCIT_C175970 subClassOf NCIT_C274 @default.
- NCIT_C175970 subClassOf NCIT_C307 @default.
- NCIT_C175970 subClassOf NCIT_C308 @default.