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- NCIT_C176028 IAO_0000115 "A bispecific monoclonal antibody against both the tumor-associated antigen (TAA) human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential antineoplastic and immunostimulating activities. Upon administration, anti-MUC16/CD28 bispecific antibody REGN5668 binds to both CD28 on T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins, is overexpressed by several epithelial cancers, including ovarian cancer." @default.
- NCIT_C176028 NCIT_A7 NCIT_C71020 @default.
- NCIT_C176028 NCIT_NHC0 "C176028" @default.
- NCIT_C176028 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C176028 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C176028 NCIT_P107 "Anti-MUC16/CD28 Bispecific Antibody REGN5668" @default.
- NCIT_C176028 NCIT_P108 "Anti-MUC16/CD28 Bispecific Antibody REGN5668" @default.
- NCIT_C176028 NCIT_P208 "CL1413425" @default.
- NCIT_C176028 NCIT_P322 "CTRP" @default.
- NCIT_C176028 NCIT_P322 "GDC" @default.
- NCIT_C176028 NCIT_P329 "803766" @default.
- NCIT_C176028 NCIT_P330 "803766" @default.
- NCIT_C176028 NCIT_P399 "803766" @default.
- NCIT_C176028 NCIT_R124 NCIT_C17710 @default.
- NCIT_C176028 NCIT_R124 NCIT_C17828 @default.
- NCIT_C176028 NCIT_R124 NCIT_C18219 @default.
- NCIT_C176028 NCIT_R124 NCIT_C19986 @default.
- NCIT_C176028 NCIT_R124 NCIT_C40474 @default.
- NCIT_C176028 normalizedInformationContent "100" @default.
- NCIT_C176028 referenceCount "1" @default.
- NCIT_C176028 hasExactSynonym "Anti-MUC16 x Anti-CD28 Bispecific Antibody REGN5668" @default.
- NCIT_C176028 hasExactSynonym "Anti-MUC16/CD28 Bispecific Antibody REGN5668" @default.
- NCIT_C176028 hasExactSynonym "MUC16xCD28 Bispecific Antibody REGN5668" @default.
- NCIT_C176028 hasExactSynonym "REGN 5668" @default.
- NCIT_C176028 hasExactSynonym "REGN-5668" @default.
- NCIT_C176028 hasExactSynonym "REGN5668" @default.
- NCIT_C176028 inSubset NCIT_C116977 @default.
- NCIT_C176028 inSubset NCIT_C116978 @default.
- NCIT_C176028 inSubset NCIT_C128784 @default.
- NCIT_C176028 inSubset NCIT_C157711 @default.
- NCIT_C176028 inSubset NCIT_C157712 @default.
- NCIT_C176028 inSubset NCIT_C176424 @default.
- NCIT_C176028 type Class @default.
- NCIT_C176028 isDefinedBy ncit.owl @default.
- NCIT_C176028 label "Anti-MUC16/CD28 Bispecific Antibody REGN5668" @default.
- NCIT_C176028 subClassOf NCIT_C176028 @default.
- NCIT_C176028 subClassOf NCIT_C1908 @default.
- NCIT_C176028 subClassOf NCIT_C1909 @default.
- NCIT_C176028 subClassOf NCIT_C20401 @default.
- NCIT_C176028 subClassOf NCIT_C307 @default.
- NCIT_C176028 subClassOf NCIT_C308 @default.